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J4580

Jasplakinolide

≥97% (HPLC), film (colorless), actin polymerization promoter

Synonyme(s) :

Jaspamide

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ConditionnementRéférenceDisponibilitéPrix
100 μg
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719,00 €

A propos de cet article

Formule empirique (notation de Hill) :
C36H45BrN4O6
Numéro CAS:
102396-24-7
Poids moléculaire :
709.67
UNSPSC Code:
12352200
PubChem Substance ID:
329815735
NACRES:
NA.77
MDL number:
MFCD00873735
Assay:
≥97% (HPLC)
Form:
film (colorless)
Quality level:
100

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Nom du produit

Jasplakinolide, ≥97% (HPLC)

Quality Level

100

assay

≥97% (HPLC)

form

film (colorless)

color

off-white to beige

solubility

DMSO: >2 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

C[C@H]1C[C@@H](C)\C=C(C)\C[C@H](C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc2c(Br)[nH]c3ccccc23)C(=O)N[C@H](CC(=O)O1)c4ccc(O)cc4

InChI

1S/C36H45BrN4O6/c1-20-15-21(2)17-23(4)47-32(43)19-30(25-11-13-26(42)14-12-25)40-35(45)31(18-28-27-9-7-8-10-29(27)39-33(28)37)41(6)36(46)24(5)38-34(44)22(3)16-20/h7-15,21-24,30-31,39,42H,16-19H2,1-6H3,(H,38,44)(H,40,45)/b20-15+/t21-,22-,23-,24-,30+,31+/m0/s1

InChI key

GQWYWHOHRVVHAP-DHKPLNAMSA-N

Application

Jasplakinolide has been used to analyze its influence on sciatic nerve guidance effect in vivo in chicken embryos. It has also been used to apply on the control cells for the treatment for blocking actin dynamics.

Biochem/physiol Actions

Jasplakinolide is an actin-specific reagent that promotes actin polymerization and stabilizes actin filaments.
Jasplakinolide is an actin-specific reagent that promotes actin polymerization and stabilizes actin filaments. In vitro, Jasplakinolidet potently induces actin polymerization by stimulating actin filament nucleation and competes with phalloidin for actin binding (Kd = 15 nM). In vivo, Jasplakinolide has been found to disrupt actin filaments and induce polymerization of monomeric actin into amorphous masses, the exact mechanism of which has not been determined yet. Jasplakinolide differs from other actin stabilizers in that it is cell permeable. This peptide has fungicidal, insecticidal and antiproliferative activity, and is useful for investigating cell processes mediated by actin polymerization and depolymerization, such as cell adhesion, locomotion, endocytosis, and vesicle sorting and release.

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Cet article
SML0494SML0358L7035
Jasplakinolide ≥97% (HPLC)

Sigma-Aldrich

J4580

Jasplakinolide

VU0361737 ≥98% (HPLC)

Sigma-Aldrich

SML0494

VU0361737

AA74-1 ≥98% (HPLC)

Sigma-Aldrich

SML0358

AA74-1

clasto-Lactacystin β-lactone

Sigma-Aldrich

L7035

clasto-Lactacystin β-lactone

form

film (colorless)

form

film

form

film

form

film

assay

≥97% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: >2 mg/mL

solubility

DMSO: 15 mg/mL (clear solution)

solubility

DMSO: >15 mg/mL

solubility

DMSO: soluble 25 mg/mL

color

off-white to beige

color

white

color

colorless

color

-

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Certificats d'analyse (COA)

Lot/Batch Number
0000221890
0000219705
0000221890
0000219705
0000155044

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Numéro d'article de commerce international

RéférenceGTIN
J4580-100UG04061833866320

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