This product is not GMP grade. Unfortunately, a GMP grade α-Ketoglutaric acid product is not currently offered. This product is intended for research use only. Unless otherwise stated this product is not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
K1128
α-Ketoglutaric acid
BioReagent, suitable for cell culture, suitable for insect cell culture
Synonym(s):
2-Oxoglutaric acid, 2-Oxopentanedioic acid
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| Size/SKU | Availability | Price |
|---|---|---|
5 g | Check Cart for Availability | $64.00 |
25 g | Check Cart for Availability | $81.60 |
100 g | Check Cart for Availability | $172.00 |
About This Item
Linear Formula:
HOOCCH2CH2COCOOH
CAS Number:
Molecular Weight:
146.10
UNSPSC Code:
12352204
NACRES:
NA.32
PubChem Substance ID:
EC Number:
206-330-3
Beilstein/REAXYS Number:
1705689
MDL number:
$64.00
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product line
BioReagent
Quality Segment
assay
≥98.5% NaOH basis (titration)
form
powder or crystals
technique(s)
cell culture | insect: suitable, cell culture | mammalian: suitable
solubility
water: 100 mg/mL, clear to slightly hazy, colorless to almost colorless
storage temp.
2-8°C
SMILES string
OC(=O)CCC(=O)C(O)=O
InChI
1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
InChI key
KPGXRSRHYNQIFN-UHFFFAOYSA-N
General description
Application
α-Ketoglutaric acid has been used:
- as a supplement in minimum essential medium α (α-MEM) to culture primary mesenchymal stromal/stem cells (MSCs) to study its effects on age-related osteoporosis
- for chemical treatments to compare the treatment effects of several compounds on lifespan between manual and automated lifespan machine (ALM) platforms
- as a printed chemotaxis ligand to screen chemotaxis receptors with high-throughput technologies and verify the interactions with surface plasmon resonance (SPR)
Biochem/physiol Actions
Alpha-ketoglutarate (αKG), a nitrogen scavenger, is an important source of glutamate and glutamine. It controls the synthesis of ATP and decreases the generation of equivalent (NAD+/NADH) in the tricarboxylic acid (TCA) cycle. It promotes the synthesis of protein and prevents protein degradation in muscles. This immune nutrient factor participates in the general immune and collagen metabolism. In aged rodents, αKG accelerates the healing of bone defects. It may possess potential anti-aging effects. This Krebs cycle molecule can be used as a supplement in insect and mammalian cell cultures.
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This Item | |||
|---|---|---|---|
| description BioReagent, suitable for cell culture, suitable for insect cell culture | description 99.0-101.0% (T) | description powder, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥97% (HPLC) | description ≥97% (HPLC) |
| assay ≥98.5% NaOH basis (titration) | assay 99.0-101.0% (T) | assay ≥97% (HPLC) | assay ≥97% (HPLC) |
| solubility water: 100 mg/mL, clear to slightly hazy, colorless to almost colorless | solubility H2O: 1 g/10 mL, clear to slightly hazy, colorless to almost colorless | solubility H2O: 100 mg/mL | solubility H2O: 100 mg/mL, clear to slightly hazy, colorless to light yellow |
| technique(s) cell culture | insect: suitable, cell culture | mammalian: suitable | technique(s) - | technique(s) cell culture | insect: suitable, cell culture | mammalian: suitable | technique(s) - |
| Quality Level 200 | Quality Level 300 | Quality Level 200 | Quality Level 200 |
| form powder or crystals | form crystals | form powder | form powder |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. −20°C |
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Signal Word
Danger
Hazard Codes
Precautionary Statements
Hazard Classifications
Eye Dam. 1
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
dust mask type N95 (US), Eyeshields, Gloves
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