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K1140

Kifunensine

solid,film or powder, ≥98%

Synonym(s):

FR 900494, Hexahydro-6R,7S,8aS-trihydroxy-5R-(hydroxymethyl)-imidazo[1,2-a] pyridine-2,3-dione

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Size/SKUAvailabilityPrice
1 mg

Available to ship TODAYfromMILWAUKEE

$305.00

About This Item

Empirical Formula (Hill Notation):
C8H12N2O6
CAS Number:
109944-15-2
Molecular Weight:
232.19
UNSPSC Code:
12352204
NACRES:
NA.77

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Product Name

Kifunensine, mannosidase inhibitor

biological source

synthetic (organic)

Quality Segment

100

assay

≥98%

form

film or powder, solid

solubility

water, double-distilled: 50 mM

storage temp.

−20°C

SMILES string

N21[C@H](NC(=O)C2=O)[C@H]([C@H]([C@@H]([C@H]1CO)O)O)O

InChI

1S/C8H12N2O6/c11-1-2-3(12)4(13)5(14)6-9-7(15)8(16)10(2)6/h2-6,11-14H,1H2,(H,9,15)/t2-,3-,4+,5+,6+/m1/s1

InChI key

OIURYJWYVIAOCW-PQMKYFCFSA-N

Gene Information

human ... MAN1A1(4121), MAN1A2(10905), MAN1B1(11253), MAN1C1(57134)
mouse ... MAN1A1(17155), MAN1A2(17156), MAN1B1(227619), MAN1C1(230815)
rat ... MAN1A1(294410), MAN1A2(295319), MAN1B1(499751), MAN1C1(362625)

General description

Kifunensine is an alkaloid compound, isolated from the actinomycete Kitasporia kifunensis.

Application

Kifunensine has been used as an inhibitor of mannosidase I in Jurkat T-cells, human embryonic kidney (HEK293T/17) cells and in mouse embryonic fibroblast cells.

Biochem/physiol Actions

Kifunensine is a selective inhibitor of class I glycoprotein-processing α-mannosidases.
Kifunensine suppresses endoplasmic reticulum-associated degradation (ERAD) via the inhibition of endoplasmic reticulum-associated mannosidase activity. It is also a glycosidase inhibitor for Class I CAZy glycosylhydrolase family 47.

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This Item
422500HPA063561EMU051701
Kifunensine mannosidase inhibitor

Sigma-Aldrich

K1140

Kifunensine

Kifunensine, Kitasatosporia kifunense A potent alkaloid inhibitor of mannosidase I.

Sigma-Aldrich

422500

Kifunensine, Kitasatosporia kifunense

Anti-MAN1A1 antibody produced in rabbit Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Sigma-Aldrich

HPA063561

Anti-MAN1A1 antibody produced in rabbit

MISSION® esiRNA targeting mouse Man1a2

Sigma-Aldrich

EMU051701

MISSION® esiRNA

description

mannosidase inhibitor

description

A potent alkaloid inhibitor of mannosidase I.

description

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

description

targeting mouse Man1a2

assay

≥98%

assay

≥95% (HPLC)

assay

-

assay

-

biological source

synthetic (organic)

biological source

-

biological source

rabbit

biological source

-

Gene Information

human ... MAN1A1(4121), MAN1A2(10905), MAN1B1(11253), MAN1C1(57134)
mouse ... MAN1A1(17155), MAN1A2(17156), MAN1B1(227619), MAN1C1(230815)
rat ... MAN1A1(294410), MAN1A2(295319), MAN1B1(499751), MAN1C1(362625)

Gene Information

-

Gene Information

human ... MAN1A1(4121)

Gene Information

mouse ... MAN1A2(17156), Man1a2(17156)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

form

solid, film or powder

form

solid

form

buffered aqueous glycerol solution

form

lyophilized powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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