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K1385

KN-93

synthetic (organic), ≥98% (HPLC),  Ca2+/calmodulin-dependent protein kinase II inhibitor, powder

Synonym(s):

N-[2-[N-(4-Chlorocinnamyl)-N-methylaminomethyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide phosphate salt, N-[2-[[[3-(4′-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4′-methoxybenzenesulfonamide phosphate salt

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0.1 mg

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0.5 mg
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$449.00
$381.65

About This Item

Empirical Formula (Hill Notation):
C26H29ClN2O4S · H3PO4
CAS Number:
139298-40-1
Molecular Weight:
599.03
UNSPSC Code:
51111800
PubChem Substance ID:
329817125
NACRES:
NA.77
MDL number:
MFCD03788201

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Product Name

KN-93, ≥98% (HPLC)

biological source

synthetic (organic)

Quality Segment

200

assay

≥98% (HPLC)

form

powder

color

white

solubility

DMSO: 1 mg/mL, H2O: soluble

storage temp.

2-8°C

SMILES string

OP(O)(O)=O.COc1ccc(cc1)S(=O)(=O)N(CCO)c2ccccc2CN(C)C\C=C\c3ccc(Cl)cc3

InChI

1S/C26H29ClN2O4S.H3O4P/c1-28(17-5-6-21-9-11-23(27)12-10-21)20-22-7-3-4-8-26(22)29(18-19-30)34(31,32)25-15-13-24(33-2)14-16-25;1-5(2,3)4/h3-16,30H,17-20H2,1-2H3;(H3,1,2,3,4)/b6-5+;

InChI key

NNKJTPOXLIILMB-IPZCTEOASA-N

Application

KN-93 has been used:
  • as an inhibitor to block αCaMKII (Ca2+/calmodulin-dependent protein kinase IIα)
  • as CaMKII inhibitor to pre-treat hippocampal slices
  • to treat the cells, to alter the cytoskeleton (CSK) structure and function during the experiment

Biochem/physiol Actions

KN-93 is a selective Ca2+/calmodulin-dependent protein kinase II inhibitor, which has been implicated in the regulation of smooth muscle contractility. CaM kinase II activation was inhibited by KN-93 pretreatment (IC50 ~1 μM). KN-93 inhibited histamine-induced tonic force maintenance, whereas early force development and MLC20 phosphorylation responses during the entire time course were unaffected. Both force development and maintenance in response to KCl were inhibited by KN-93. Rapid increases in KCl-induced MLC20 phosphorylation were also inhibited by KN-93, whereas steady-state MLC20 phosphorylation responses were unaffected. In contrast, phorbol 12,13-dibutyrate (PDBu) did not activate CaM kinase II and PDBu-stimulated force development was unaffected by KN-93. Thus KN-93 appears to target a step(s) essential for force maintenance in response to physiological stimuli, suggesting a role for CaM kinase II in regulating tonic contractile responses in arterial smooth muscle. Pharmacological activation of protein kinase C bypasses the KN-93 sensitive step.
KN-93 is a selective Ca2+/calmodulin-dependent protein kinase II inhibitor.

Features and Benefits

This compound is featured on the Ca/CaMKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
422708SML2960422709
KN-93 ≥98% (HPLC)

Sigma-Aldrich

K1385

KN-93

KN-93 A cell-permeable, reversible and competitive inhibitor of rat brain CaM kinase II (Ki = 370 nM).

Sigma-Aldrich

422708

KN-93

Nizatidine ≥98% (HPLC)

Sigma-Aldrich

SML2960

Nizatidine

KN-92 KN-92, CAS 1135280-28-2, is useful as a negative control for KN-93 (Cat. No. 422708), a Ca2+/CaM Kinase II inhibitor.

Sigma-Aldrich

422709

KN-92

description

≥98% (HPLC)

description

A cell-permeable, reversible and competitive inhibitor of rat brain CaM kinase II (Ki = 370 nM).

description

≥98% (HPLC)

description

KN-92, CAS 1135280-28-2, is useful as a negative control for KN-93 (Cat. No. 422708), a Ca2+/CaM Kinase II inhibitor.

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

biological source

synthetic (organic)

biological source

-

biological source

-

biological source

-

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

form

powder

form

solid

form

powder

form

viscous liquid

solubility

DMSO: 1 mg/mL, H2O: soluble

solubility

DMSO: 5 mg/mL

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 5 mg/mL

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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