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K1632

Kininogen high molecular weight, Two Chain from human plasma

lyophilized powder

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Size/SKUAvailabilityPrice
0.1 mg
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$145.00

About This Item

UNSPSC Code:
12352202
NACRES:
NA.61
MDL number:
MFCD00131428
Form:
lyophilized powder
Biological source:
human plasma

$145.00

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biological source

human plasma

Quality Segment

200

form

lyophilized powder

solubility

H2O: soluble 0.1 mg protein/mL

UniProt accession no.

P01042

storage temp.

−20°C

Gene Information

human ... KNG1(3827), KNG1 (includes EG:3827)

General description

HK (KNG1) gene is mapped to human chromosome 3q27.3. It is a glycoprotein.[1]
High-molecular-weight kininogen (HK) is the substrate and cofactor of the plasma kallikrein-kinin system (KKS). It is present at a concentration of 660 nM on the plasma and binds to platelet GPI-V-IX complex.

Biochem/physiol Actions

High molecular weight kininogen, two chain, is a participant in contact phase activation of the intrinsic blood coagulation cascade that forms a substrate on which blood factor XI is held in proximity to factor XII allowing reciprocal activation of the two factors. It is also involved in the activation of prekallikrein. High molecular weight kininogen binds to proteoglycans on the surface of platelets, endothelial cells, and other cell types. Domain 5 of high molecular weight kininogen inhibits platelet aggregation and angiogenesis.
High-molecular-weight kininogen (HK) inhibits binding of thrombin to platelets.[2]

Packaging

Package size based on protein content

Physical form

Lyophilized from 4 mM sodium acetate, pH 5.3, 0.15 M NaCl

Preparation Note

Prepared by kallikrein digestion of human kininogen. Purified to remove kallikrein and kinin.

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This Item
H9291F4883F0287
Kininogen high molecular weight, Two Chain from human plasma lyophilized powder

Sigma-Aldrich

K1632

Kininogen high molecular weight, Two Chain from human plasma

Hemopexin from human plasma ≥95% (SDS-PAGE), lyophilized powder

Sigma-Aldrich

H9291

Hemopexin from human plasma

Fibrinogen from human plasma 35-65% protein (≥90% of protein is clottable).

Sigma-Aldrich

F4883

Fibrinogen from human plasma

Fibronectin Proteolytic Fragment from human plasma lyophilized powder, 70 kDa

Sigma-Aldrich

F0287

Fibronectin Proteolytic Fragment from human plasma

description

lyophilized powder

description

≥95% (SDS-PAGE), lyophilized powder

description

35-65% protein (≥90% of protein is clottable).

description

lyophilized powder, 70 kDa

biological source

human plasma

biological source

human plasma

biological source

human plasma

biological source

human plasma

form

lyophilized powder

form

lyophilized powder

form

powder

form

lyophilized powder

Gene Information

human ... KNG1(3827), KNG1 (includes EG:3827)(3827)

Gene Information

human ... HPX(3263)

Gene Information

human ... FGA(2243), FGB(2244), FGG(2266)

Gene Information

human ... FN1(2335)

UniProt accession no.

P01042

UniProt accession no.

-

UniProt accession no.

P02671, P02675, P02679

UniProt accession no.

P02751

solubility

H2O: soluble 0.1 mg protein/mL

solubility

-

solubility

0.9% NaCl: soluble

solubility

water: soluble ≥0.500 mg/mL, clear to slightly hazy, colorless

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Storage Class

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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