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K1632

Kininogen high molecular weight, Two Chain from human plasma

lyophilized powder

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0.1 mg
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$120.00

About This Item

UNSPSC Code:
12352202
NACRES:
NA.61
MDL number:
MFCD00131428
Form:
lyophilized powder
Biological source:
human plasma

$120.00

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biological source

human plasma

Quality Segment

200

form

lyophilized powder

solubility

H2O: soluble 0.1 mg protein/mL

UniProt accession no.

P01042

storage temp.

−20°C

Gene Information

human ... KNG1(3827), KNG1 (includes EG:3827)

General description

HK (KNG1) gene is mapped to human chromosome 3q27.3. It is a glycoprotein.[1]
High-molecular-weight kininogen (HK) is the substrate and cofactor of the plasma kallikrein-kinin system (KKS). It is present at a concentration of 660 nM on the plasma and binds to platelet GPI-V-IX complex.

Biochem/physiol Actions

High molecular weight kininogen, two chain, is a participant in contact phase activation of the intrinsic blood coagulation cascade that forms a substrate on which blood factor XI is held in proximity to factor XII allowing reciprocal activation of the two factors. It is also involved in the activation of prekallikrein. High molecular weight kininogen binds to proteoglycans on the surface of platelets, endothelial cells, and other cell types. Domain 5 of high molecular weight kininogen inhibits platelet aggregation and angiogenesis.
High-molecular-weight kininogen (HK) inhibits binding of thrombin to platelets.[2]

Packaging

Package size based on protein content

Physical form

Lyophilized from 4 mM sodium acetate, pH 5.3, 0.15 M NaCl

Preparation Note

Prepared by kallikrein digestion of human kininogen. Purified to remove kallikrein and kinin.

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Kininogen high molecular weight, Two Chain from human plasma lyophilized powder

Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

F0287

Fibronectin Proteolytic Fragment from human plasma

description

lyophilized powder

description

≥95% (SDS-PAGE), lyophilized powder

description

Native, single chain, high molecular weight Kininogen from human plasma.

description

lyophilized powder, 70 kDa

biological source

human plasma

biological source

human plasma

biological source

-

biological source

human plasma

form

lyophilized powder

form

lyophilized powder

form

liquid

form

lyophilized powder

UniProt accession no.

P01042

UniProt accession no.

-

UniProt accession no.

-

UniProt accession no.

P02751

Gene Information

human ... KNG1(3827), KNG1 (includes EG:3827)(3827)

Gene Information

human ... HPX(3263)

Gene Information

-

Gene Information

human ... FN1(2335)

solubility

H2O: soluble 0.1 mg protein/mL

solubility

-

solubility

-

solubility

water: soluble ≥0.500 mg/mL, clear to slightly hazy, colorless

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−70°C

storage temp.

−20°C

Storage Class

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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