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K1632

Kininogen high molecular weight, Two Chain from human plasma

lyophilized powder

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Size/SKUAvailabilityPrice
0.1 mg

Available to ship TODAYfromMILWAUKEE

$120.00

About This Item

UNSPSC Code:
12352202
NACRES:
NA.61
MDL number:
MFCD00131428
Form:
lyophilized powder
Biological source:
human plasma

$120.00

Available to ship TODAYDetails

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biological source

human plasma

Quality Segment

form

lyophilized powder

solubility

H2O: soluble 0.1 mg protein/mL

UniProt accession no.

storage temp.

−20°C

Gene Information

General description

HK (KNG1) gene is mapped to human chromosome 3q27.3. It is a glycoprotein.
High-molecular-weight kininogen (HK) is the substrate and cofactor of the plasma kallikrein-kinin system (KKS). It is present at a concentration of 660 nM on the plasma and binds to platelet GPI-V-IX complex.

Biochem/physiol Actions

High-molecular-weight kininogen (HK) inhibits binding of thrombin to platelets.
High molecular weight kininogen, two chain, is a participant in contact phase activation of the intrinsic blood coagulation cascade that forms a substrate on which blood factor XI is held in proximity to factor XII allowing reciprocal activation of the two factors. It is also involved in the activation of prekallikrein. High molecular weight kininogen binds to proteoglycans on the surface of platelets, endothelial cells, and other cell types. Domain 5 of high molecular weight kininogen inhibits platelet aggregation and angiogenesis.

Packaging

Package size based on protein content

Physical form

Lyophilized from 4 mM sodium acetate, pH 5.3, 0.15 M NaCl

Preparation Note

Prepared by kallikrein digestion of human kininogen. Purified to remove kallikrein and kinin.

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This Item
422686F4883SAB5701001
Kininogen high molecular weight, Two Chain from human plasma lyophilized powder

Sigma-Aldrich

K1632

Kininogen high molecular weight, Two Chain from human plasma

Kininogen, High Molecular Weight, Single Chain, Human Plasma Native, single chain, high molecular weight Kininogen from human plasma.

Sigma-Aldrich

422686

Kininogen, High Molecular Weight, Single Chain, Human Plasma

Fibrinogen from human plasma 35-65% protein (≥90% of protein is clottable).

Sigma-Aldrich

F4883

Fibrinogen from human plasma

Anti-Kininogen 1 (KNG1) antibody produced in rabbit

Sigma-Aldrich

SAB5701001

Anti-Kininogen 1 (KNG1) antibody produced in rabbit

description

lyophilized powder

description

Native, single chain, high molecular weight Kininogen from human plasma.

description

35-65% protein (≥90% of protein is clottable).

description

-

biological source

human plasma

biological source

-

biological source

human plasma

biological source

rabbit

form

lyophilized powder

form

liquid

form

powder

form

liquid

solubility

H2O: soluble 0.1 mg protein/mL

solubility

-

solubility

0.9% NaCl: soluble

solubility

-

UniProt accession no.

P01042

UniProt accession no.

-

UniProt accession no.

P02679, P02675, P02671

UniProt accession no.

P01042

storage temp.

−20°C

storage temp.

−70°C

storage temp.

−20°C

storage temp.

−20°C

Gene Information

human ... KNG1(3827), KNG1 (includes EG:3827)(3827)

Gene Information

-

Gene Information

human ... FGA(2243), FGB(2244), FGG(2266)

Gene Information

human ... KNG1(3827)

Storage Class

13 - Non Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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