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K2389

Kainic acid monohydrate

From Digenea simplex, ≥98% (HPLC), Kainate glutamate receptor agonist, powder

Synonym(s):

2-Carboxy-3-carboxymethyl-4-isopropenylpyrrolidine

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Size/SKUAvailabilityPrice
10 mg
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$428.00
50 mg
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$1,710.00

About This Item

Empirical Formula (Hill Notation):
C10H15NO4 · H2O
CAS Number:
Molecular Weight:
231.25
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$428.00


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Product Name

Kainic acid monohydrate, ≥98% (HPLC), from Digenea simplex

biological source

Digenea simplex

Quality Segment

assay

≥98% (HPLC)

form

powder

color

white

solubility

H2O: >10 mg/mL

storage temp.

2-8°C

SMILES string

O.CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O

InChI

1S/C10H15NO4.H2O/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13;/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15);1H2/t6-,7+,9-;/m0./s1

InChI key

FZNZRJRSYLQHLT-SLGZUKMRSA-N

Application

Kainic acid monohydrate has been used:
  • As a convulsant to induce epileptogenesis and epilepsy in mice.
  • To stimulate in vitro excitotoxic trauma in spiral ganglion neurons on inner hair cells.
  • To induce seizures in rat model.
  • To induce status epilepticus in adult male Wistar rats.

Biochem/physiol Actions

Agonist for kainate class of ionotropic glutamate receptors.
Kainic acid monohydrate is an agonist at the kainate class of ionotropic glutamate receptors, which induces seizures and neurodegeneration in vivo and is used to induce experimental epilepsy in rodents and study the mechanisms of excitation-induced neuronal apoptosis.
Ionotropic glutamate receptors form ion channels, and conduct Na+ and K+ fluxes. The receptors possess an agonist binding site and it encounters a conformational change upon agonist binding to it. Kainate gated channels participate in glutamate-induced excitatory postsynaptic neuronal potential.

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This Item
K0250D1064420318
form

powder

form

powder

form

powder

form

solid

assay

≥98% (HPLC)

assay

≥99% (TLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

200

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

H2O: >10 mg/mL

solubility

H2O: soluble

solubility

H2O: >10 mg/mL

solubility

dilute base: 10 mg/mL, water: 10 mg/mL

color

white

color

-

color

-

color

off-white


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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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