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K4894

Poloxamer 188

solid

Synonym(s):

Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol), Lutrol F68

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Size/SKUAvailabilityPrice
500 g

Available to ship TODAYfromMILWAUKEE

$152.00

About This Item

CAS Number:
UNSPSC Code:
12161902
NACRES:
NA.75
MDL number:

$152.00


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Quality Segment

agency

USP/NF, meets USP testing specifications

form

solid

mol wt

8.400 g/mol

pH

5.0-7.5(2.5% solution)

application(s)

sample preservation

SMILES string

O2C(C2)C.O1CC1

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

General description

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Poloxamer 188 is a non-ionic amphiphilic copolymer, which has a central chain of hydrophobic polyoxypropylene and a hydrophilic polyoxyethylene at the ends.

Application

Poloxamer 188 has been used as a supplement in F17 medium for the culture of HEK293-6E cells. It has also been used as a component of flow cytometry (FACS) buffer as a non-ionic detergent that protects cells from hydrodynamic damage.
Poloxamer 188 has been used as a component of cell-dissociation/minimal essential media (MEM) to sort tumor cells using EpCAM antibody-conjugated magnetic beads.

Biochem/physiol Actions

Poloxamer 188 exhibits cytoprotective, hemorheological, anti-inflammatory, antithrombotic activities. It maintains the stability of membrane barrier function. P188 lowers surface tension and hydrophobic-based cellular adherence. It also inhibits lipid peroxidation stimulated by Fe2+ and H2O2.

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10%, sterile-filtered, BioReagent, suitable for insect cell culture

form

solid

form

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form

solid

form

-

application(s)

sample preservation

application(s)

pharmaceutical (small molecule)

application(s)

-

application(s)

-

mol wt

8.400 g/mol

mol wt

-

mol wt

~7680-9510 g/mol

mol wt

average mol wt 8350

Quality Level

300

Quality Level

-

Quality Level

200

Quality Level

400

pH

5.0-7.5(2.5% solution)

pH

-

pH

5.0-7.5 (100 g/L in H2O), 6.0-7.5 (25 g/L in H2O)

pH

-

agency

USP/NF, meets USP testing specifications

agency

-

agency

-

agency

-


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Storage Class

11 - Combustible Solids



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Questions

  1. How long can a 0,001% solution be stored at 4°C?

    1 answer
    1. The stability of a 0.001% solution at 4°C has not been tested. A solution of 100 mg/ml in water is stable for 1 year at -80°C and for 1 month at -20°C. It is recommended to aliquot the stock solutions to avoid repeated freeze-thaw cycles.

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