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Anti-LAMP1−Cy3^™ antibody produced in rabbit

Name: Anti-LAMP1−Cy3<SUP>™</SUP> antibody produced in rabbit
Brand: SIGMA
Price: 642 USD
Availability: InStock

1-2 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-CD107a, Anti-LAMPA, Anti-LGP120, Anti-Lysosomal-associated membrane protein 1

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Size/SKU	Availability	Price
200 μL	Check Cart for Availability	$642.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD01864611

Conjugate:

CY3 conjugate

Clone:

polyclonal

Application:

IF (d)

Citations:

$642.00

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Properties

biological source

rabbit

Quality Segment

200

conjugate

CY3 conjugate

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, human, rat

concentration

1-2 mg/mL

technique(s)

direct immunofluorescence: 1-2 μg/mL using human HeLa cells, rat NRK cells and mouse 3T3 cells

UniProt accession no.

P11279

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... LAMP1(3916)
mouse ... Lamp1(16783)
rat ... Lamp1(25328)

Description

General description

Lysosomal-associated membrane protein 1 (LAMP1), also termed LGP120, is a heavily glycosylated lysosomal membrane protein with a molecular mass of 120 kDa. It consists of a 40 kDa core polypeptide with O-linked and 18 asparagine-linked oligosaccharide side chains. LAMP1 protein contains a leader sequence, a large intralumenal region consisting of 2 homologous domains separated by a hinge region rich in proline and serine, a 24-amino acid transmembrane region, and a short cytoplasmic tail containing the lysosomal membrane targeting signal.

The gene LAMP1 (lysosomal-associated membrane protein 1) encodes a type I transmembrane protein that has a short cytoplasmic tail containing a lysosome-targeting signal of GYQTI(382)-COOH. The gene is mapped to human chromosome 13q34.

Application

Anti-LAMP1-Cy3^™ antibody produced in rabbit has been used in immunofluorescence.

Biochem/physiol Actions

The gene LAMP1 (lysosomal associated membrane protein 1) encodes a membrane glycoprotein that functions as an intracellular receptor. It is found to be expressed in the cytoplasm of several types of tumor cells and may be involved in tumor invasion. Lamp1 is crucial for perforin trafficking to the lytic granules and motility of these lytic granules. Its knockdown leads to inhibition of cytotoxicity of human natural killer cells.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Legal Information

Cy3 is a trademark of Cytiva

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	L1418	AMAB91299	AMAB91170
Sigma-Aldrich L0419 Anti-LAMP1−Cy3^™ antibody produced in rabbit	Sigma-Aldrich L1418 Anti-LAMP1 antibody produced in rabbit	Sigma-Aldrich AMAB91299 Monoclonal Anti-LAMP1 antibody produced in mouse	Sigma-Aldrich AMAB91170 Monoclonal Anti-LAMP1 antibody produced in mouse
description 1-2 mg/mL, affinity isolated antibody, buffered aqueous solution	description affinity isolated antibody, buffered aqueous solution	description Prestige Antibodies^® Powered by Atlas Antibodies, clone CL4472, purified immunoglobulin	description Prestige Antibodies^® Powered by Atlas Antibodies, clone CL3484, purified immunoglobulin, buffered aqueous glycerol solution
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form purified immunoglobulin
biological source rabbit	biological source rabbit	biological source mouse	biological source mouse
conjugate CY3 conjugate	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
clone polyclonal	clone polyclonal	clone CL4472, monoclonal	clone CL3484, monoclonal

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Storage Class

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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