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L-165,041

Name: L-165,041
Brand: SIGMA

≥98% (HPLC), powder

Synonym(s):

4-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxyacetic acid

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₂₆O₇

CAS Number:

79558-09-1

Molecular Weight:

402.44

NACRES:

NA.77

PubChem Substance ID:

24278477

UNSPSC Code:

12352200

MDL number:

MFCD04974501

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

protect from light, under inert gas

Pricing and availability is not currently available.

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Properties

Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

protect from light, under inert gas

color

off-white

mp

127-128 °C (lit.)

solubility

DMSO: >10 mg/mL

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

CCCc1c(O)c(ccc1OCCCOc2ccc(OCC(O)=O)cc2)C(C)=O

InChI

1S/C22H26O7/c1-3-5-19-20(11-10-18(15(2)23)22(19)26)28-13-4-12-27-16-6-8-17(9-7-16)29-14-21(24)25/h6-11,26H,3-5,12-14H2,1-2H3,(H,24,25)

InChI key

HBBVCKCCQCQCTJ-UHFFFAOYSA-N

Gene Information

human ... PPARD(5467)

Description

Application

L-165,041 has been used as a peroxisome proliferator-activated receptor β/δ (PPARβ/δ) ligand to study its influence on PPARβ/δ mediated postnatal myogenesis in C2C12 myoblasts.

Biochem/physiol Actions

L-165041 dose-dependently blocks rat vascular smooth muscle cell (VSMC) proliferation and migration by inducing the cell cycle arrest. It has the potential to treat pathological cardiovascular conditions, such as restenosis and atherosclerosis. L-165041 also effectively inhibits the progression of diabetic nephropathy. It exhibits anti-apoptosis and anti-angiogenic effects.

PPARβ (PPARδ) selective agonist.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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This Item	422175	SML0083	SML0230
Sigma-Aldrich L2167 L-165,041	Sigma-Aldrich 422175 L-165,041	Sigma-Aldrich SML0083 GSK 1059615 sodium salt hydrate	Sigma-Aldrich SML0230 GW-803430
description ≥98% (HPLC), powder	description A cell-permeable phenoxyacetic acid derivative that acts as a potent and selective peroxisome proliferator activator receptor δ (PPARδ) agonist (K_i = 6 nM for hPPARδ and 730 nM for hPPARγ).	description -	description ≥98% (HPLC)
form powder	form solid	form powder	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay -	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
storage condition protect from light, under inert gas	storage condition OK to freeze, protect from light	storage condition -	storage condition -
solubility DMSO: >10 mg/mL	solubility 1 M NaOH: 40 mg/mL, DMSO: 5 mg/mL	solubility H₂O: ≥8 mg/mL	solubility DMSO: ≥4 mg/mL at warmed to 60 °C

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Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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