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L2898

Lysostaphin from Staphylococcus staphylolyticus

aseptically filled

Synonym(s):

Glycyl-glycine Endopeptidase

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Size/SKUAvailabilityPrice
1 mg
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$458.00

About This Item

CAS Number:
9011-93-2
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
3.4.24.75 (BRENDA, IUBMB)
MDL number:
MFCD00131556
Specific activity:
>500 units/mg protein

$458.00

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sterility

aseptically filled

Quality Segment

form

powder

specific activity

>500 units/mg protein

mol wt

25 kDa

composition

Protein, 40-70% biuret

input

bacteria and yeast sample(s)

antibiotic activity spectrum

Gram-positive bacteria

mode of action

cell wall synthesis | interferes

storage temp.

−20°C

General description

Lysostaphin is mainly liberated as a proenzyme. It is highly stable at pH 4 and temperature 5°C.
Chemical structure: peptide

Biochem/physiol Actions

Lysostaphin exhibit a lytic action against Staphylococcus aureus. It possesses several functions of three major enzymes, such as, glycylglycine endopeptidase, endo-β-N-acetyl glucosamidase and N-acteyl muramyl-L-alanine amidase. Lysostaphin can be used to treat antibiotic-resistant staphylococcal infections. Lysostaphin being an antistaphylococcal agent, can be used as a preservative in the food industry and in clinical labs for rapid screening.
Lysostaphin is a zinc endopeptidase with a molecular weight of approximately 25 kDa. Because lysostaphin cleaves the polyglycine cross-links in the peptidoglycan layer of the cell wall of Staphylococcus species it has been found useful for cell lysis and also as a potential anti-microbial therapeutic.
pH Optimum for activity: ~7.5

Preparation Note

Prepared from L 7386

Other Notes

One unit will reduce the turbidity (A620) of a suspension of Staphylococcus aureus cells from 0.250 to 0.125 in 10 min at pH 7.5 at 37 °C in a 6.0 ml reaction mixture.

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L4402SAE0091L7386
Lysostaphin from Staphylococcus staphylolyticus aseptically filled

Sigma-Aldrich

L2898

Lysostaphin from Staphylococcus staphylolyticus

Lysostaphin from Staphylococcus staphylolyticus BioUltra, ≥97% (SDS-PAGE), Protein 40-60 % by biuret, ≥2,000 units/mg protein

Sigma-Aldrich

L4402

Lysostaphin from Staphylococcus staphylolyticus

Lysostaphin from Staphylococcus staphylolyticus free of DNA contaminants, suitable for Microbiome research, lyophilized powder, ≥500 units/mg protein

Sigma-Aldrich

SAE0091

Lysostaphin from Staphylococcus staphylolyticus

Lysostaphin from Staphylococcus staphylolyticus lyophilized powder, Protein 50-70 % by biuret, ≥500 units/mg protein

Sigma-Aldrich

L7386

Lysostaphin from Staphylococcus staphylolyticus

description

aseptically filled

description

BioUltra, ≥97% (SDS-PAGE), Protein 40-60 % by biuret, ≥2,000 units/mg protein

description

free of DNA contaminants, suitable for Microbiome research, lyophilized powder, ≥500 units/mg protein

description

lyophilized powder, Protein 50-70 % by biuret, ≥500 units/mg protein

specific activity

>500 units/mg protein

specific activity

≥2,000 units/mg protein

specific activity

≥500 units/mg protein

specific activity

≥500 units/mg protein

form

powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

mol wt

25 kDa

mol wt

25 kDa

mol wt

27 kDa

mol wt

25 kDa

sterility

aseptically filled

sterility

-

sterility

-

sterility

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

200

Quality Level

300

Quality Level

-

Quality Level

300

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Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Codes

H334

Precautionary Statements

P261 - P284 - P501

Hazard Classifications

Resp. Sens. 1

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000582354
    0000493980
    049K8701
    021M8724
    SLCR3968

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    Questions

    1. Which reaction buffer is recommended for this enzyme? Are there any limitations, inhibitors, etc? Would it work in any medium.

      1 answer

      1. Please see the link below to the quality control test procedure utilized for the enzymatic assay of lysostaphin. Reaction with other buffers has not been tested and, please refer to academic literature for guidance on how other buffers may influence the enzyme's reactivity:

        https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/120/423/l7386enz.pdf

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