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L7386

Lysostaphin from Staphylococcus staphylolyticus

≥500 units/mg protein, lyophilized powder

Synonym(s):

Glycyl-glycine Endopeptidase

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1 MG

$132.00

5 MG

$404.00

15 MG

$981.00

$132.00

Available to ship onDecember 02, 2025Details

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About This Item

CAS Number:
9011-93-2
EC Number:
3.4.24.75 (BRENDA, IUBMB)
MDL number:
MFCD00131556
UNSPSC Code:
12352204
NACRES:
NA.54

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Product Name

Lysostaphin from Staphylococcus staphylolyticus, lyophilized powder, Protein 50-70 % by biuret, ≥500 units/mg protein

biological source

microbial (Staphylococcus staphylotyticus)

Quality Level

300

form

lyophilized powder

specific activity

≥500 units/mg protein

mol wt

25 kDa

composition

Protein, 50-70% biuret

packaging

pkg of (sold on basis of mg protein)

solubility

water: 2.00-2.10 mg/mL, clear to slightly hazy, colorless to light yellow

antibiotic activity spectrum

Gram-positive bacteria

application(s)

diagnostic assay manufacturing
diagnostic assay manufacturing

mode of action

cell wall synthesis | interferes

shipped in

wet ice

storage temp.

−20°C

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This Item
SAE0091SRE0053L2898
Lysostaphin from Staphylococcus staphylolyticus lyophilized powder, Protein 50-70 % by biuret, ≥500 units/mg protein

Sigma-Aldrich

L7386

Lysostaphin from Staphylococcus staphylolyticus

Lysostaphin from Staphylococcus staphylolyticus free of DNA contaminants, suitable for Microbiome research, lyophilized powder, ≥500 units/mg protein

Sigma-Aldrich

SAE0091

Lysostaphin from Staphylococcus staphylolyticus

Lysostaphin from Staphylococcus staphylolyticus Suitable for manufacturing of diagnostic kits and reagents., lyophilized powder

Sigma-Aldrich

SRE0053

Lysostaphin from Staphylococcus staphylolyticus

Lysostaphin from Staphylococcus staphylolyticus aseptically filled

Sigma-Aldrich

L2898

Lysostaphin from Staphylococcus staphylolyticus

biological source

microbial (Staphylococcus staphylotyticus)

biological source

microbial (Staphylococcus staphylotyticus)

biological source

bacterial (Staphylococcus sp.)

biological source

-

Quality Level

300

Quality Level

-

Quality Level

400

Quality Level

200

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

powder

solubility

water: 2.00-2.10 mg/mL, clear to slightly hazy, colorless to light yellow

solubility

-

solubility

-

solubility

-

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

General description

Chemical structure: peptide

Biochem/physiol Actions

Lysostaphin is a zinc endopeptidase with a molecular weight of approximately 25 kDa. Because lysostaphin cleaves the polyglycine cross-links in the peptidoglycan layer of the cell wall of Staphylococcus species it has been found useful for cell lysis and also as a potential anti-microbial therapeutic.
pH Optimum for activity: ~7.5

Other Notes

One unit will reduce the turbidity (A620) of a suspension of Staphylococcus aureus cells from 0.250 to 0.125 in 10 min at pH 7.5 at 37°C in a 6.0 ml reaction mixture.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H334

Hazard Classifications

Resp. Sens. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000487998
0000487998
0000480156
0000467804
0000467804

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Judy J J Ou et al.
Frontiers in cellular and infection microbiology, 6, 187-187 (2017-01-14)
Background:Staphylococcus aureus (S. aureus) small colony variants (SCVs) can survive within the host intracellular milieu and are associated with chronic relapsing infections. However, it is unknown whether host invasion rates and immune responses differ between SCVs and their wild-type counterparts.
Ian R Monk et al.
Nature communications, 10(1), 3067-3067 (2019-07-13)
WalKR (YycFG) is the only essential two-component regulator in the human pathogen Staphylococcus aureus. WalKR regulates peptidoglycan synthesis, but this function alone does not explain its essentiality. Here, to further understand WalKR function, we investigate a suppressor mutant that arose
Catherine Bennett et al.
International forum of allergy & rhinology, 9(8), 918-925 (2019-06-05)
Chronic rhinosinusitis (CRS) is a common disease, often refractory to conventional antimicrobial treatment. In this study we investigate the antimicrobial and anti-inflammatory effects of adding kappa-carrageenan to a commercially available sinus rinse. Kappa-carrageenan was added to Flo CRS and Flo
Ching-Ying Huang et al.
Animal biotechnology, 24(2), 129-147 (2013-03-29)
Lysostaphin (LYS) is an anti-staphylococcal prokaryotic polypeptide that has been used to avoid Staphylococcus aureus mastitis through transgenic or viral vector approaches exogenously expressed in dairy animals. However, glycosylation of lysostaphin expressed in mammalian cells results in a loss of
Aradhana A Vipra et al.
BMC microbiology, 12, 41-41 (2012-03-24)
Bacterial drug resistance is one of the most significant challenges to human health today. In particular, effective antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA) are urgently needed. A causal relationship between nasal commensal S. aureus and infection has been reported.
View All Related Papers

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