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M0319

MRS 2578

≥95% (HPLC)

Synonym(s):

1,4-Di[3-(3-isothiocyanatophenyl)thioureido]butane

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$165.00
$171.00
25 mg

Available to ship TODAYfromMILWAUKEE

$630.00
$535.50

About This Item

Empirical Formula (Hill Notation):
C20H20N6S4
CAS Number:
Molecular Weight:
472.67
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥95% (HPLC)
Form:
powder
Storage condition:
desiccated

$171.00

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Quality Segment

assay

≥95% (HPLC)

form

powder

storage condition

desiccated

color

white

solubility

DMSO: >5 mg/mL, H2O: insoluble

storage temp.

2-8°C

SMILES string

S=C=Nc1cccc(NC(=S)NCCCCNC(=S)Nc2cccc(c2)N=C=S)c1

InChI

1S/C20H20N6S4/c27-13-23-15-5-3-7-17(11-15)25-19(29)21-9-1-2-10-22-20(30)26-18-8-4-6-16(12-18)24-14-28/h3-8,11-12H,1-2,9-10H2,(H2,21,25,29)(H2,22,26,30)

InChI key

QOHNRGHTJPFMSL-UHFFFAOYSA-N

Application

MRS 2578 has been used an antagonist of purinoceptor P2Y6:
  • to study the role of purinergic receptor in Up4A-induced relaxation in coronary small arteries from swine
  • in P. aeruginosa infected mice to test its effect on the inflammatory responses
  • to test its inhibition on neutrophil extracellular traps and monosodium urate (MSU) crystals formation in polymorphonuclear leukocytes

Biochem/physiol Actions

MRS 2578 elicits cytoprotective functionality in neuroblastoma cells and prevents dopaminergic neuron death under in vitro and in vivo conditions. It also protects microglia by delaying lipopolysaccharide-induced death.
Potent and irreversible antagonist of P2Y6 nucleotide receptor.

Features and Benefits

This compound is featured on the P2 Receptors: P2Y G-Protein Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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M227M594269966
description

≥95% (HPLC)

description

solid

description

≥98% (HPLC), solid

description

NutriSelect® Basic, powder, for Lactobacillus spp., for Bifidobacterium spp., pack of 500 g

assay

≥95% (HPLC)

assay

-

assay

≥98% (HPLC)

assay

-

form

powder

form

solid

form

solid

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

-

storage temp.

-

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

solubility

DMSO: >5 mg/mL, H2O: insoluble

solubility

H2O: insoluble, DMSO: >10 mg/mL, ethanol: >10 mg/mL

solubility

DMSO: >10 mg/mL, H2O: insoluble

solubility

-


Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Faceshields, Gloves



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