The solubility and solution stability of this product has not been determined. However, historical data indicate the material is soluble in DMSO at 100 mM. It is recommended to store stock solutions in aliquots, protected from light, at -80 °C. Stock solutions may be filter-sterilized. Note that alkaline and reducing agents will degrade the solution.
M5750
Menadione sodium bisulfite
synthetic, ≥95% (TLC), Prothrombogenic compound, powder
Synonym(s):
2-Methyl-1,4-naphthoquinone sodium bisulfite
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| Size/SKU | Availability | Price |
|---|---|---|
25 g | Available to ship TODAYfromMILWAUKEE | $68.80 |
100 g | Available to ship TODAYfromMILWAUKEE | $186.00 |
1 kg | Available to ship TODAYfromMILWAUKEE | $927.00 |
About This Item
Empirical Formula (Hill Notation):
C11H9NaO5S
CAS Number:
Molecular Weight:
276.24
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
204-987-0
MDL number:
Assay:
≥95% (TLC)
Form:
powder
Product Name
Menadione sodium bisulfite, ≥95% (TLC)
biological source
synthetic
Quality Segment
assay
≥95% (TLC)
form
powder
color
white to off-white
solubility
H2O: ≥50 mg/mL, clear, colorless to faintly yellow
application(s)
cell analysis
originator
Eli Lilly
storage temp.
−20°C
SMILES string
[Na+].CC1(CC(=O)c2ccccc2C1=O)S([O-])(=O)=O
InChI
1S/C11H10O5S.Na/c1-11(17(14,15)16)6-9(12)7-4-2-3-5-8(7)10(11)13;/h2-5H,6H2,1H3,(H,14,15,16);/q;+1/p-1
InChI key
XDPFHGWVCTXHDX-UHFFFAOYSA-M
Application
Menadione sodium bisulfite has been used:
- as a priming agent in tomato for improving salt tolerance
- to induce reactive oxygen species (ROS) in human lung epithelium BEAS-2B microtissues
- to induce endogenous superoxide production in mouse C17.2 neural stem cells
Biochem/physiol Actions
Menadione sodium bisulfite is a water-soluble form of menadione, which belongs to the Vitamin K class of compounds. These are necessary for the biosynthesis of prothrombin and other blood clotting factors. Menadione is a prothrombogenic compound and is used as a model quinone in cell culture and in vivo investigations.
Menadione has been shown to affect gap-junctional intercellular communication by mediation of tyrosine phosphorylation. Menadione has demonstrated cytotoxic activity against a variety of cell lines and can induce apoptosis in cultured cells, such as osteoclasts and osteoblasts, via elevation of peroxide and superoxide radical levels.
An HPLC method for detection of menadione sodium bisulfite in multivitamin formulations has been published. A chemiluminescence assay for menadione sodium bisulfite in pharmaceutical preparations and biological fluids has been reported.
Menadione has been shown to affect gap-junctional intercellular communication by mediation of tyrosine phosphorylation. Menadione has demonstrated cytotoxic activity against a variety of cell lines and can induce apoptosis in cultured cells, such as osteoclasts and osteoblasts, via elevation of peroxide and superoxide radical levels.
An HPLC method for detection of menadione sodium bisulfite in multivitamin formulations has been published. A chemiluminescence assay for menadione sodium bisulfite in pharmaceutical preparations and biological fluids has been reported.
Features and Benefits
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Other Notes
Water soluble vitamin K3.
1 of 1
This Item | |||
|---|---|---|---|
| description ≥95% (TLC) | description BioReagent, suitable for cell culture, ≥95% (TLC) | description ACS reagent | description purum, ~40% |
| form powder | form powder | form powder or crystals | form liquid |
| assay ≥95% (TLC) | assay ≥95% (TLC) | assay - | assay - |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| storage temp. −20°C | storage temp. −20°C | storage temp. - | storage temp. - |
| solubility H2O: ≥50 mg/mL, clear, colorless to faintly yellow | solubility water: soluble 50 mg/mL, clear, colorless to light yellow | solubility - | solubility - |
| color white to off-white | color white to off-white | color - | color - |
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Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
dust mask type N95 (US), Eyeshields, Gloves
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At what temperature should the solution be stored? Is it acceptable to freeze the solution and thaw it later? If so, can it be re-frozen after thawing, or should freeze-thaw cycles be avoided? What is the shelf-life once diluted in water?
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