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Anti-MeCP2 antibody, Mouse monoclonal

Name: Anti-MeCP2 antibody, Mouse monoclonal
Brand: SIGMA
Price: 201 USD
Availability: InStock

clone Men-8, purified from hybridoma cell culture

Synonym(s):

Anti-AUTSX3, Anti-MRX16, Anti-MRX79, Anti-MRXS13, Anti-MRXSL, Anti-PPMX, Anti-RS, Anti-RTS, Anti-RTT

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Size/SKU	Availability	Price
25 μL	Available to ship TODAYfromMILWAUKEE	$201.00
200 μL	Available to ship TODAYfromMILWAUKEE	$735.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD02686372

Conjugate:

unconjugated

Clone:

Men-8, monoclonal

Application:

ARR, ELISA (i), ICC, WB

Citations:

$201.00

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Properties

Quality Segment

200

biological source

mouse

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

Men-8, monoclonal

form

buffered aqueous solution

mol wt

antigen ~75 kDa

species reactivity

mouse, human, rat, monkey

packaging

antibody small pack of 25 μL

technique(s)

immunocytochemistry: suitable, indirect ELISA: suitable, microarray: suitable, western blot: 1-2 μg/test using nuclear extract of cultured human acute T cell leukemia Jurkat cells or MCF7 cells

isotype

IgG1

UniProt accession no.

P51608

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MECP2(4204)
mouse ... Mecp2(17257)
rat ... Mecp2(29386)

Description

General description

Methyl-CpG binding protein 2 (MeCP2) possesses a methyl-CpG-binding domain (MBD) and a transcriptional repression domain.

Monoclonal Anti-MeCP2 (mouse IgG1 isotype) is derived from the Men-8 hybridoma produced by the fusion of mouse myeloma cells (NS1) and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to the N-terminus of human MeCP2.

Immunogen

synthetic peptide corresponding to the N-terminus (amino acids 15-30) of human MeCP2.

Application

Monoclonal Anti-MeCP2 antibody has been used:

in western blotting
in immunoblotting
in flow cytometry
in immunohistofluorescence
in immunocytochemistry

Biochem/physiol Actions

MeCP2 (methyl-CpG binding protein 2) silences transcription by recruiting the histone deacetylase (HDAC) repressive machinery via recruitment of the Sin 3A corepressor, thus removing acetyl groups from histones and consequently, silencing genes.

Methyl-CpG binding protein 2 (MeCP2) has been shown be crucial for brain development. It part of the methyl-CpG-binding proteins, which are involved in repression of gene expression by binding to methylated DNA. Mutations in the gene encoding MeCP2 have been associated with Rett syndrome (RTT).

Physical form

Solution in 0.01 M phosphate buffered saline containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	M6818	SAB4200366	WH0004204M1
Sigma-Aldrich M7443 Anti-MeCP2 antibody, Mouse monoclonal	Sigma-Aldrich M6818 Anti-MeCP2 antibody, Mouse monoclonal	Sigma-Aldrich SAB4200366 Anti-IKZF1/IKAROS antibody, Mouse monoclonal	Sigma-Aldrich WH0004204M1 Monoclonal Anti-MECP2 antibody produced in mouse
description clone Men-8, purified from hybridoma cell culture	description clone Mec-168, purified from hybridoma cell culture	description clone E1.14, purified from hybridoma cell culture	description clone 4B6, purified immunoglobulin, buffered aqueous solution
biological source mouse	biological source mouse	biological source mouse	biological source mouse
Gene Information human ... MECP2(4204) mouse ... Mecp2(17257) rat ... Mecp2(29386)	Gene Information human ... MECP2(4204) mouse ... Mecp2(17257) rat ... Mecp2(29386)	Gene Information human ... IKZF1(10320)	Gene Information human ... MECP2(4204)
clone Men-8, monoclonal	clone Mec-168, monoclonal	clone E1.14, monoclonal	clone 4B6, monoclonal
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
species reactivity mouse, human, rat, monkey	species reactivity rat, human, mouse	species reactivity rat, monkey, human, mouse	species reactivity mouse
antibody form purified from hybridoma cell culture	antibody form purified from hybridoma cell culture	antibody form purified from hybridoma cell culture	antibody form purified immunoglobulin

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Storage Class

12 - Non Combustible Liquids

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