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MSST0031

SILu™Prot MAPT Microtubule-associated protein tau-441 human

recombinant, expressed in HEK 293 cells, SIL MS Protein Standard, 13C and 15N-labeled

Synonym(s):

Isotopically labeled MAPT LC/MS standard, Isotopically labeled human Microtubule-associated protein tau-441, Neurofibrillary tangle protein human, Paired helical filament-tau (PHF-tau), Pairedhelicalfilament-tau(PHF-tau), Tau-F

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Size/SKUAvailabilityPrice
10 μg

Available to ship TODAYfromMILWAUKEE

$846.00
$719.10

About This Item

NACRES:
NA.12
UNSPSC Code:
23201100
Form:
lyophilized powder
Assay:
≥98% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in HEK 293 cells

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biological source

human

Quality Segment

200

recombinant

expressed in HEK 293 cells

assay

≥98% (SDS-PAGE)

form

lyophilized powder

potency

≥98 Heavy amino acids incorporation efficiency by MS

technique(s)

mass spectrometry (MS): suitable

suitability

suitable for mass spectrometry (standard)

UniProt accession no.

P10636

storage temp.

−20°C

Gene Information

human ... MAPT(4137)

General description

Tau-441 is a member of the Tau family of proteins. Tau proteins are mainly expressed in the neurons of the central nervous system where they exert a role in stabilizing microtubules, key components of axonal transport, as well as in signal transduction.Tau proteins are subject to phosphorylation and this phenomenon regulates the association of the Tau protein with the microtubules. Deposits of Alzheimer′s disease AD-associated proteins, such as hyperphosphorylated Tau, as well as other shared misfolded proteins, such as, β-amyloid precursor protein (βAPP), ubiquitin, and various chaperones and protein kinases are thought to play a pathologic role in the cognitive decline and muscular failure.3 Malfunctioning of Tau proteins is associated with microtubules disintegration and collapsing of the neuronal transport system. Among other diseases, Tau forms in cerebrospinal fluid are considered a reliable biomarker for progressive supranuclear palsy, where the levels of Tau forms ratio were significantly reduced.

Immunogen

MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGLDRIRGRKLGPFEGKPIPNPLLGLDSTRTGHHHHHHHHGGQ

Biochem/physiol Actions

SILu™Prot MAPT is a recombinant, stable isotope-labeled human MAPT which incorporates [13C6, 15N4]-Arginine and [13C6, 15N2]-Lysine. Expressed in human 293 cells, it is designed to be used as an internal standard for bioanalysis of MAPT in mass-spectrometry. SILu Prot MAPT is a protein of 481 amino acids (including C-terminal V5 and polyhistidine tags) with a calculated molecular mass of 36 kDa.

Physical form

Supplied as a lyophilized powder containing phosphate buffered saline.

Legal Information

This product is licensed under U.S. Patent No. 7,396,688 and foreign counterparts from E. I. du Pont de Nemours and Company. The purchase of this product conveys to the buyer the nontransferable right to use the purchased amount of the product for research and development only, including services for a third party for consideration. The buyer cannot sell or otherwise transfer this product, its components or materials made using this product or its components to a third party. Information about licenses for excluded uses is available from: E. I. du Pont de Nemours and Company; Attn: Associate Director, Commercial Development; DuPont Experimental Station E268; 200 Powdermill Rd.; Wilmington, DE 19803; 1-877-881-9787 (voice), 1-302-695-1437 (fax), licensing@dupont.com.
SILu is a trademark of Sigma-Aldrich Co. LLC

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SAE0076MSST0032ABN454
SILu™Prot MAPT Microtubule-associated protein tau-441 human recombinant, expressed in HEK 293 cells, SIL MS Protein Standard, 13C and 15N-labeled

Sigma-Aldrich

MSST0031

SILu™Prot MAPT Microtubule-associated protein tau-441 human

Tau-441 human recombinant, lyophilized powder, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

Sigma-Aldrich

SAE0076

Tau-441 human

SILu™Lite MAPT Microtubule-associated protein tau-441 human recombinant, expressed in HEK 293 cells, MS Protein Standard

Sigma-Aldrich

MSST0032

SILu™Lite MAPT Microtubule-associated protein tau-441 human

Anti-Tau (T22), oligomeric Antibody serum, from rabbit

Sigma-Aldrich

ABN454

Anti-Tau (T22), oligomeric Antibody

description

recombinant, expressed in HEK 293 cells, SIL MS Protein Standard, 13C and 15N-labeled

description

recombinant, lyophilized powder, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

description

recombinant, expressed in HEK 293 cells, MS Protein Standard

description

serum, from rabbit

biological source

human

biological source

human

biological source

human

biological source

rabbit

technique(s)

mass spectrometry (MS): suitable

technique(s)

cell based assay: suitable

technique(s)

mass spectrometry (MS): suitable

technique(s)

immunofluorescence: suitable, western blot: suitable, ELISA: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable, neutralization: suitable, dot blot: suitable

recombinant

expressed in HEK 293 cells

recombinant

expressed in HEK 293 cells

recombinant

expressed in HEK 293 cells

recombinant

-

assay

≥98% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

≥98% (SDS-PAGE)

assay

-

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

-

suitability

suitable for mass spectrometry (standard)

suitability

-

suitability

suitable for mass spectrometry (internal calibrator)

suitability

-

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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