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MSST0032

SILu™Lite MAPT Microtubule-associated protein tau-441 human

recombinant, expressed in HEK 293 cells, MS Protein Standard

Synonym(s):

Neurofibrillary tangle protein, Paired helical filament-tau (PHF-tau), Pairedhelicalfilament-tau(PHF-tau), Tau-F

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50 μg
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$813.00

About This Item

NACRES:
NA.12
UNSPSC Code:
23201100
Form:
lyophilized powder
Assay:
≥98% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in HEK 293 cells
Mol wt:
calculated mol wt 50 kDa

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biological source

human

Quality Segment

200

recombinant

expressed in HEK 293 cells

tag

8-His tagged, V5 tagged

assay

≥98% (SDS-PAGE)

form

lyophilized powder

potency

≥98% Heavy amino acids incorporation efficiency by MS

mol wt

calculated mol wt 50 kDa

technique(s)

mass spectrometry (MS): suitable

suitability

suitable for mass spectrometry (internal calibrator)

UniProt accession no.

P02649

storage temp.

−20°C

Gene Information

human ... MAPT(4137)

General description

Tau-441 is a member of the Tau family of proteins. Tau proteins are mainly expressed in the neurons of the central nervous system where they exert a role in stabilizing microtubules, key components of axonal transport, as well as in signal transduction.Tau proteins are subject to phosphorylation and this phenomenon regulates the association of the Tau protein with the microtubules. Deposits of Alzheimer′s disease AD-associated proteins, such as hyperphosphorylated Tau, as well as other shared misfolded proteins, such as, β-amyloid precursor protein (βAPP), ubiquitin, and various chaperones and protein kinases are thought to play a pathologic role in the cognitive decline and muscular failure.3 Malfunctioning of Tau proteins is associated with microtubules disintegration and collapsing of the neuronal transport system Among other diseases, Tau forms in cerebrospinal fluid are considered a reliable biomarker for progressive supranuclear palsy, where the levels of Tau forms ratio were significantly reduced.

Immunogen

MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGLDRIRGRKLGPFEGKPIPNPLLGLDSTRTGHHHHHHHHGGQ

Biochem/physiol Actions

SILu™Lite MAPT is a recombinant human protein expressed in human 293 cells. It consists of 481 amino acids (including C-terminal V5 and polyhistidine tags), with a calculated molecular mass of 50 kDa. SILu Lite MAPT is an analytical standard designed to be used as starting material for preparation of calibrators and controls in LC-MS applications.

Physical form

Supplied as a lyophilized powder containing phosphate buffered saline.

Legal Information

SILu is a trademark of Sigma-Aldrich Co. LLC

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SAE0076MSST0031ABN454
SILu™Lite MAPT Microtubule-associated protein tau-441 human recombinant, expressed in HEK 293 cells, MS Protein Standard

Sigma-Aldrich

MSST0032

SILu™Lite MAPT Microtubule-associated protein tau-441 human

Tau-441 human recombinant, lyophilized powder, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

Sigma-Aldrich

SAE0076

Tau-441 human

SILu™Prot MAPT Microtubule-associated protein tau-441 human recombinant, expressed in HEK 293 cells, SIL MS Protein Standard, 13C and 15N-labeled

Sigma-Aldrich

MSST0031

SILu™Prot MAPT Microtubule-associated protein tau-441 human

Anti-Tau (T22), oligomeric Antibody serum, from rabbit

Sigma-Aldrich

ABN454

Anti-Tau (T22), oligomeric Antibody

description

recombinant, expressed in HEK 293 cells, MS Protein Standard

description

recombinant, lyophilized powder, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

description

recombinant, expressed in HEK 293 cells, SIL MS Protein Standard, 13C and 15N-labeled

description

serum, from rabbit

assay

≥98% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

≥98% (SDS-PAGE)

assay

-

biological source

human

biological source

human

biological source

human

biological source

rabbit

recombinant

expressed in HEK 293 cells

recombinant

expressed in HEK 293 cells

recombinant

expressed in HEK 293 cells

recombinant

-

technique(s)

mass spectrometry (MS): suitable

technique(s)

cell based assay: suitable

technique(s)

mass spectrometry (MS): suitable

technique(s)

ELISA: suitable, dot blot: suitable, immunofluorescence: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable, neutralization: suitable, western blot: suitable

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

-

mol wt

calculated mol wt 50 kDa

mol wt

calculated mol wt 50.3 kDa (including c-terminal His and V5 tags), observed mol wt 70-100 kDa by SDS-PAGE (The protein migrates as a 70-110 kDa protein on SDS-PAGE due to glycosylation)

mol wt

-

mol wt

-

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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