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MSST0048

SILu™Lite SOST, Sclerostin human

recombinant, expressed in HEK 293 cells, MS Protein Standard

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50 μg
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$811.00

About This Item

NACRES:
NA.12
UNSPSC Code:
23201100
Form:
lyophilized powder
Assay:
≥98% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in HEK 293 cells

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biological source

human

Quality Segment

200

recombinant

expressed in HEK 293 cells

tag

8-His tagged

assay

≥98% (SDS-PAGE)

form

lyophilized powder

technique(s)

mass spectrometry (MS): suitable

suitability

suitable for mass spectrometry (internal calibrator)

UniProt accession no.

Q9BQB4

storage temp.

−20°C

Gene Information

human ... SOST(50964)

General description

SILu™Lite SOST is a recombinant human protein expressed in human 293 cells. It consists of 201 amino acids (including a N-terminal polyhistidine and tag), with a calculated molecular mass of 22.8 kDa. SILu™Lite SOST is an analytical standard designed to be used as starting material for preparation of calibrators and controls in LC-MS applications.

Biochem/physiol Actions

Sclerostin is a secreted Wnt signaling antagonist produced almost exclusively by osteocytes. It can selectively inhibit Wnt/ β-catenin, suppressing the activity of osteoblasts as well as the viability of osteoblasts and osteocytes. Lower sclerostin levels are associated with lower bone mineral content and bone. It was demonstrated that greater total limb bone mineral content was significantly associated with greater circulating levels of sclerostin. In addition, circulating sclerostin is a biomarker of osteoporosis severity in long-term, chronic paraplegia. Serum sclerostin was associated significantly, independently, and positively with bone mineral density of both cortical and cancellous bone. Sclerostin is considered to be one of the factors associated with chronic kidney disease-mineral and bone disorder in hemodialysis patients.

Physical form

Supplied as a lyophilized powder containing phosphate buffered saline.

Other Notes

HHHHHHHHGGQQGWQAFKNDATEIIPELGEYPEPPPELENNKTMNRAENGGRPPHHPFETKDVSEYSCRELHFTRYVTDGPCRSAKPVTELVCSGQCGPARLLPNAIGRGKWWRPSGPDFRCIPDRYRAQRVQLLCPGGEAPRARKVRLVASCKCKRLTRFHNQSELKDFGTEAARPQKGRKPRPRARSAKANQAELENAY

Legal Information

SILu is a trademark of Sigma-Aldrich Co. LLC

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description

recombinant, expressed in HEK 293 cells, MS Protein Standard

description

recombinant, expressed in HEK 293 cells, SIL MS Protein Standard, 13C and 15N-labeled

description

recombinant, expressed in HEK 293 cells, MS Protein Standard

description

recombinant, expressed in HEK 293 cells, MS protein standard

recombinant

expressed in HEK 293 cells

recombinant

expressed in HEK 293 cells

recombinant

expressed in HEK 293 cells

recombinant

expressed in HEK 293 cells

technique(s)

mass spectrometry (MS): suitable

technique(s)

mass spectrometry (MS): suitable

technique(s)

mass spectrometry (MS): suitable

technique(s)

mass spectrometry (MS): suitable

biological source

human

biological source

human

biological source

human

biological source

human

assay

≥98% (SDS-PAGE)

assay

≥98% (SDS-PAGE)

assay

≥98% (SDS-PAGE)

assay

≥98% (SDS-PAGE)

suitability

suitable for mass spectrometry (internal calibrator)

suitability

suitable for mass spectrometry (standard)

suitability

suitable for mass spectrometry (internal calibrator)

suitability

suitable for mass spectrometry (internal calibrator)

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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