MTOX1304
Canine MDR1 Knockout, Human BCRP Knockin MDCKII Cells
canine kidney (cocker spaniel)
Synonym(s):
MDCKII MDR1 KO hBCRP knockin
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| Size/SKU | Availability | Price |
|---|---|---|
1 vial | Usually ships in 3 weeks. | $1,480.00 |
About This Item
UNSPSC Code:
12352207
NACRES:
NA.81
Biological source:
canine kidney (cocker spaniel)
Product Name
Canine MDR1 Knockout, Human BCRP Knockin MDCKII Cells,
biological source
canine kidney (cocker spaniel)
Quality Segment
form
liquid
storage temp.
−196°C
Gene Information
human ... ABCG2(9429)
Application
See technical bulletin for detailed protocols
Features and Benefits
MDCK II - Madin-Darby canine kidney- is a subclone derived from the heterogenous parent line - MDCK (ECACC catalogue no. 85011435) MDCK II cells, which predominate in later passages from MDCK, are reported to display electrical resistance of 100 ohm/cm2. This strain is thought to be derived from the distal tubule or collecting duct of the nephron. The cell line can be used as an experimental model to study the generation and maintenance of cell surface polarity in epithelial cells.
The canine MDR1 (cP-gp) efflux transporter gene has been effectively disrupted in both alleles. There is no expression of the cP-gp. Human BCRP has been transfected into the MDCKII cell line. Validation studies have shown efflux of standard BCRP substrates.
Analysis Note
Tested for Mycoplasma, sterility, post-freeze viability, short terminal repeat (STR) analysis for cell line identification.
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This Item | |||
|---|---|---|---|
| description - | description - | description - | description - |
| biological source canine kidney (cocker spaniel) | biological source canine kidney (cocker spaniel) | biological source canine kidney (cocker spaniel) | biological source canine kidney (cocker spaniel) |
| storage temp. −196°C | storage temp. −196°C | storage temp. −196°C | storage temp. −196°C |
| Quality Level 200 | Quality Level - | Quality Level 200 | Quality Level 200 |
| Gene Information human ... ABCG2(9429) | Gene Information human ... ABCG2(9429) | Gene Information human ... ABCB1(5243) | Gene Information - |
| form liquid | form liquid | form liquid | form liquid |
Storage Class
10 - Combustible liquids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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