Thaw this product in the refrigerator at 2–8°C. The product is stored frozen at -20°C and shipped on dry ice. Nystatin activity can be affected by heat, light, and oxygen; avoid prolonged exposure to room temperature. After thawing, mix gently and keep the container tightly closed.
N1638
Nystatin Suspension
suspension, non-animal origin, suitable for cell culture, BioReagent
Synonym(s):
Fungicidin, Mycostatin
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| Size/SKU | Availability | Price |
|---|---|---|
20 mL | Check Cart for Availability | $27.20 |
100 mL | Check Cart for Availability | $71.10 |
Product Name
Nystatin Suspension, suspension, 10,000 unit/mL in DPBS, BioReagent, suitable for cell culture
product line
BioReagent
Quality Segment
form
suspension
concentration
10,000 unit/mL in DPBS
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
color
yellow
antibiotic activity spectrum
fungi, yeast
mode of action
cell membrane | interferes
shipped in
dry ice
storage temp.
−20°C
SMILES string
C[C@@H]1OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@]2(O)C[C@H](O)[C@H]([C@H](C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\C=C\C=C\C=C\C=C\CC\C=C\C=C\[C@H](C)[C@@H](O)[C@@H]1C)O2)C(O)=O
InChI
1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28+,29-,30+,31+,32+,33+,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1
InChI key
VQOXZBDYSJBXMA-QEKUPDCNSA-N
General description
Chemical structure: polyene
Application
Nystatin suspension has been used:
- to inhibit caveolin-mediated endocytosis
- as a component of Eagle′s minimum essential medium (EMEM)
- to enumerate lactic acid bacteria (LAB)
- in preventing cell culture contamination and inducing interleukin (IL)-1, IL-8, and tumor necrosis factor a secretion in toll-like receptor 2 (TLR2)-expressing THP1 cells.
Biochem/physiol Actions
Nystatin is a polyene, broad-spectrum antibiotic, which modifies the microstructure of lipid rafts. It can sequester cholesterol present on the cell membrane of eukaryotes. Nystatin regulates immune responses through cytokine signaling, lymphocyte activation and pathogen recognition.
Preparation Note
It is 0.1μ filtered and cell culture tested.
Other Notes
Nystatin suspension available in 20 mL and 100 mL pack size.
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Disclaimer
This product is stable at 37°C for three days.
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This Item | |||
|---|---|---|---|
| description suspension, 10,000 unit/mL in DPBS, BioReagent, suitable for cell culture | description United States Pharmacopeia (USP) Reference Standard | description powder, BioReagent, suitable for cell culture | description European Pharmacopoeia (EP) Reference Standard |
| antibiotic activity spectrum yeast, fungi | antibiotic activity spectrum - | antibiotic activity spectrum yeast, fungi | antibiotic activity spectrum - |
| mode of action cell membrane | interferes | mode of action - | mode of action cell membrane | interferes | mode of action - |
| technique(s) cell culture | mammalian: suitable | technique(s) - | technique(s) cell culture | mammalian: suitable | technique(s) - |
| product line BioReagent | product line - | product line BioReagent | product line - |
| Quality Level 200 | Quality Level - | Quality Level 200 | Quality Level - |
| form suspension | form solid | form powder | form - |
Storage Class
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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Should this product be thawed at room temperature or in the refrigerator?
1 answer-
Helpful?
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Product N1638 , Nystatin Suspension consists of 10,000 units/mL Nystatin in Dulbecco′s Phosphate Buffered Saline. What does "unit" stand for? If I want 50 mg of this product how much equivalent volume will it be?
1 answer-
The unit definition for Nystatin is based on the USP reference standard, and its potency is assessed using the USP Nystatin standard. The initial material, nystatin, possesses a unit activity ranging from 4500 to 5000 units/mg. The preparation in question has an approximate potency of 10,000 units/mL, suggesting that the concentration is likely to be around 2 mg/mL. It should be noted that this is a suspension of nystatin in Dulbecco's Phosphate Buffered Saline (DPBS), not merely in water.
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