Osteocalcin, Human, product number O5761 is carboxylated.
Post-translational modification by a vitamin K dependent carboxylase produces three g-carboxyglutamic acid residues at positions 17, 21 and 24. The mature protein contains 49 amino acids and a single intrachain disulfide bond joining Cys23 to Cys29.
O5761
Osteocalcin fragment 1-49 Human
≥94% (HPLC), solid
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| Size/SKU | Availability | Price |
|---|---|---|
500 μg | Check Cart for Availability | $976.00 |
1 mg | Check Cart for Availability | $1,810.00 |
About This Item
Empirical Formula (Hill Notation):
C269H381N67O82S2
CAS Number:
Molecular Weight:
5929.43
UNSPSC Code:
12352200
NACRES:
NA.32
MDL number:
Quality Segment
assay
≥94% (HPLC)
form
solid
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... BGLAP(632)
General description
Bone γ-carboxyglutamate protein (BGLAP) or osteocalcin (OCN) is a non-collagenous bone matrix protein expressed by osteoblasts. It possesses a Gla (γ carboxyglutamate) domain. The gene encoding OCN is localized on human chromosome 1q22.
Calcium-binding protein found in dentin and possibly other mineralized tissues.
Application
Human osteocalcin fragment 1-49 has been used for the identification and characterization of glycation adducts on osteocalcin. It has also been used to study its effects on the differentiation of mouse myoblast cell line C2C12.
Biochem/physiol Actions
Bone γ-carboxyglutamate protein (BGLAP) regulates osteogenic differentiation of mesenchymal stromal cells. It has a role in bone turnover and mineralization. The protein also has a role in energy metabolism. BGLAP may act as a mediator between glucose metabolism and bone tissue.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
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This Item | |||
|---|---|---|---|
| description ≥94% (HPLC), solid | description clone 2D4, purified immunoglobulin, buffered aqueous solution | description - | description for cell culture supernatants, plasma, and serum samples |
| assay ≥94% (HPLC) | assay - | assay - | assay - |
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level - |
| form solid | form buffered aqueous solution | form liquid | form - |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. - |
| Gene Information human ... BGLAP(632) | Gene Information human ... BGLAP(632) | Gene Information human ... BGLAP(632) | Gene Information human ... BGLAP(632) |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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