The lab has not validated the product for use in animal studies. For the injection of 5-Pregnen-3β-ol-20-one-16α-carbonitrile using a vehicle solution, a publication suggests that 5% dimethyl sulfoxide in safflower oil may be effective. This finding was published in the Journal of Nuclear Medicine, July 2020 issue, Volume 61, Issue 7, on pages 1050-1057. The publication, titled "Imaging P-Glycoprotein Induction at the Blood-Brain Barrier of a β-Amyloidosis Mouse Model with 11C-Metoclopramide PET," is indexed with PMID: 31806767.
P0543
5-Pregnen-3β-ol-20-one-16α-carbonitrile
synthetic (organic), ≥97%, glucocorticoid receptor antagonist, powder, crystals or chunks
Synonym(s):
Pregnenolone-16α-carbonitrile
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| Size/SKU | Availability | Price |
|---|---|---|
50 mg | Check Cart for Availability | $92.00 $95.30 |
100 mg | Check Cart for Availability | $165.00 $140.25 |
250 mg | Check Cart for Availability | $319.00 $271.15 |
About This Item
Empirical Formula (Hill Notation):
C22H31NO2
CAS Number:
Molecular Weight:
341.49
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥97%
Form:
powder, crystals or chunks
Product Name
5-Pregnen-3β-ol-20-one-16α-carbonitrile, ≥97%
biological source
synthetic (organic)
Quality Segment
sterility
non-sterile
assay
≥97%
form
powder, crystals or chunks
technique(s)
cell culture | mammalian: suitable
solubility
chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow (with heat)
shipped in
ambient
storage temp.
2-8°C
SMILES string
C[C@@]12[C@](C[C@@H](C#N)[C@@H]2C(C)=O)([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC1
InChI
1S/C22H31NO2/c1-13(24)20-14(12-23)10-19-17-5-4-15-11-16(25)6-8-21(15,2)18(17)7-9-22(19,20)3/h4,14,16-20,25H,5-11H2,1-3H3/t14-,16-,17+,18-,19-,20-,21-,22-/m0/s1
InChI key
VSBHRRMYCDQLJF-ZDNYCOCVSA-N
Application
5-Pregnen-3β-ol-20-one-16α-carbonitrile has been used:
- in the induction of cytochrome P450
- as pregnane X receptor (PXR) activator in human liver cell lines.
Biochem/physiol Actions
Pregnenolone-16a-carbonitrile (PCN) is a glucocorticoid receptor antagonist and a PXR (pregnane X receptor) activator.
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This Item | |||
|---|---|---|---|
| description ≥97% | description ≥98% | description - | description ≥98% |
| form powder, crystals or chunks | form powder | form powder | form powder |
| assay ≥97% | assay ≥98% | assay ≥98% (TLC) | assay ≥98% |
| Quality Level 100 | Quality Level 200 | Quality Level 100 | Quality Level 100 |
| technique(s) cell culture | mammalian: suitable | technique(s) - | technique(s) - | technique(s) - |
| storage temp. 2-8°C | storage temp. room temp | storage temp. room temp | storage temp. - |
| solubility chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow (with heat) | solubility ethanol: soluble 10 mg/mL, clear, colorless to faintly yellow | solubility chloroform: 50 mg/mL, clear, colorless | solubility - |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
>199.9 °F - closed cup
Flash Point (°C)
> 93.3 °C - closed cup
PPE (personal protective equipment)
Eyeshields, Gloves, type N95 (US)
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What delivery solvent is recommended for IP injection of 5-Pregnen-3β-ol-20-one-16α-carbonitrile into mice?
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