Key Documents

View All Documentation

Platelet-Derived Growth Factor-BB human

Name: Platelet-Derived Growth Factor-BB human
Brand: SIGMA
Price: 576 CAD
Availability: InStock

≥98% (HPLC and SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(s):

PDGF-BB

Select a Size

Change View

Pack Size	SKU	Availability	Price
10 μg		Estimated to ship onMay 11, 2026fromMilliporeSigma Canada Ltd.	$576.00
50 μg		Please contact Customer Service for Availability	$1,290.00

About This Item

UNSPSC Code:

12352202

NACRES:

NA.77

MDL number:

MFCD00213023

Biological source:

human

Recombinant:

expressed in E. coli

Assay:

≥98% (HPLC and SDS-PAGE)

Form:

lyophilized powder

Mol wt:

~25 kDa

Impurities:

≤1 EU/μg

$576.00

Estimated to ship onMay 11, 2026Details

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Product Name

Platelet-Derived Growth Factor-BB human, PDGF-BB, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

biological source

human

Quality Level

200

recombinant

expressed in E. coli

assay

≥98% (HPLC and SDS-PAGE)

form

lyophilized powder

potency

1.0-3.0 ng/mL EC₅₀

quality

endotoxin tested

mol wt

~25 kDa

packaging

pkg of 10 μg, pkg of 50 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

≤1 EU/μg

UniProt accession no.

P01127

storage temp.

−20°C

Gene Information

human ... PDGFB(5155)

Description

General description

Platelet-derived growth factor (PDGF) is expressed as homo and heterodimers : PDGF-AB FDGF-AA, PDGF-BB, PDGF-CC and PDGF-DD. The PDGF gene is highly conserved mapped to human chromosome 7p22.3. The active form of Pdgf exists as disulfide-linked dimers. It consists of cystine-knot-fold growth factor domain, which is highly conserved, except for the N-terminal prodomain, which shows variation in length among the isoforms.

Application

Platelet-Derived Growth Factor-BB human has been used :

As a growth supplement in proximal tubule and glomerular explant cell culture
In three-dimensional scaffold preparation
To study the effect of brivanib on growth factor signaling pathways
In transwell migration assay

Biochem/physiol Actions

Platelet-derived growth factor (PDGF) elicits multifunctional actions with a variety of cells. It is mitogenic to mesoderm-derived cells, such as dermal and tendon fibroblasts, vascular smooth muscle cells, glial cells, and chondrocytes. PDGF significantly activates chemotaxis of neutrophils, monocytes, and fibroblasts.[1] It increases the synthesis of phospholipids, cholesterol esters, glycogen and prostaglandins, and modulates LDL (low density lipoprotein) receptor binding.
PDGF stimulates fibroblast proliferation and extracellular matrix production in order to facilitate tissue repair. PDGF-BB isomer is found to be critical in angiogenesis and is highly expressed in tumor, mediating oncogenic pericyte recruitment. PDGF-BB is an important regulator of bone homeostasis, repair and regeneration.

Physical form

Lyophilized from a 0.2 μm filtered solution in 30 mM acetic acid.

Analysis Note

The biological activity is measured by its ability to stimulate ³H-thymidine incorporation in quiescent NR6R-3T3 fibroblasts.

Other Notes

Dimer of the B chain of human PDGF.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item	P4306	P3326	SRP3138
Sigma-Aldrich P3201 Platelet-Derived Growth Factor-BB human	Sigma-Aldrich P4306 Platelet-Derived Growth Factor-BB human	Sigma-Aldrich P3326 Platelet-Derived Growth Factor-AB human	Sigma-Aldrich SRP3138 PDGF-BB human
recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant expressed in E. coli
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable
assay ≥98% (HPLC and SDS-PAGE)	assay ≥97% (SDS-PAGE)	assay ≥97% (SDS-PAGE and N-terminal analysis)	assay ≥98% (HPLC), ≥98% (SDS-PAGE)
biological source human	biological source human	biological source human	biological source human
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level -
form lyophilized powder	form lyophilized powder	form lyophilized powder	form lyophilized

Still not finding the right product?

Explore all of our products under Platelet-Derived Growth Factor-BB human

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

0000478729

0000513041

0000482676

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Articles

Platelet Derived Growth Factors (PDGF)

Platelet-Derived Growth Factor is the principal mitogen found in mammalian serum and is released from platelets during clot formation.

Global Trade Item Number

SKU	GTIN
P3201-10UG	04061834367475
P3201-50UG	04061834367482

Questions

Reviews

No rating value