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P4365

PJ-34 hydrochloride hydrate

≥98% (HPLC), powder

Synonym(s):

PARP Inhibitor VIII, PJ 34 HCl, N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-(N,N-dimethylamino)acetamide hydrochloride

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Size/SKUAvailabilityPrice
5 mg
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$319.00
$331.00

About This Item

Empirical Formula (Hill Notation):
C17H17N3O2 · HCl · xH2O
CAS Number:
Molecular Weight:
331.80 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated

$331.00

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Quality Segment

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to yellow

solubility

H2O: 22 mg/mL

SMILES string

Cl[H].[H]O[H].CN(C)CC(=O)Nc1ccc2NC(=O)c3ccccc3-c2c1

InChI

1S/C17H17N3O2.ClH.H2O/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15;;/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22);1H;1H2

InChI key

YCALIZUKAFUQCH-UHFFFAOYSA-N

Application

PJ-34 hydrochloride hydrate has been used:
  • as a poly(ADP-ribose) polymerase (PARP) inhibitor 1 in rats to test the effect of PAPR1 in neuropathic pain
  • as a component of protein extraction buffer to enable visualization of the high-molecular-weight smear of PARylated proteins in various cell samples
  • as PARP inhibitor in murine MLE-12 epithelial cell line

Biochem/physiol Actions

PJ-34 is a prototypic poly(ADP-ribose) polymerase 1 (PARP-1) inhibitor.
PJ-34 is a potent poly(ADP-ribose) polymerase (PARP) inhibitor.

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This Item
SML3873BPS78371P0996
description

≥98% (HPLC), powder

description

≥98% (HPLC)

description

-

description

recombinant, expressed in E. coli

form

powder

form

powder

form

-

form

solution

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

assay

-

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

200

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

solubility

H2O: 22 mg/mL

solubility

DMSO: 2 mg/mL, clear

solubility

-

solubility

-

color

white to yellow

color

white to beige

color

-

color

-


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)



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