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P4458
Penicillin-Streptomycin
liquid, non-animal origin, suitable for cell culture, BioReagent
Penicillin-Streptomycin
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Synonym(s):
Pen-Strep
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 20 mL | Please contact Customer Service for Availability | $21.80 | |
| 100 mL | Estimated to ship TODAYfromMilliporeSigma Canada Ltd. | $42.70 |
About This Item
UNSPSC Code:
12352207
NACRES:
NA.76
Product Name
Penicillin-Streptomycin, Solution Stabilized, with 5,000 units penicillin and 5mg streptomycin/mL, 0.1 μm filtered, BioReagent, suitable for cell culture
Quality Level
sterility
0.1 μm filtered
product line
BioReagent
form
liquid
concentration
50 ×
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
cell wall synthesis | interferes, protein synthesis | interferes
shipped in
dry ice
storage temp.
−20°C
SMILES string
CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(O)=O.CNC[C@H]4[C@H](O)[C@@H](O)[C@H](CCO)O[C@H]4O[C@H]5[C@@H](O[C@@H](C)C5(O)C=O)O[C@H]6[C@H](O)[C@@H](O)[C@H](NC(N)=N)[C@@H](O)[C@@H]6NC(N)=N
InChI
1S/C23H43N7O12.C16H18N2O4S/c1-7-23(38,6-32)18(42-19-8(5-28-2)12(33)13(34)9(40-19)3-4-31)20(39-7)41-17-11(30-22(26)27)14(35)10(29-21(24)25)15(36)16(17)37;1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9/h6-20,28,31,33-38H,3-5H2,1-2H3,(H4,24,25,29)(H4,26,27,30);3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22)/t7-,8-,9-,10+,11-,12-,13-,14+,15-,16+,17+,18-,19-,20-,23+;11-,12+,14-/m01/s1
InChI key
KMOOCZWLFBSQCW-XFOLRDBHSA-N
General description
Penicillin, a β-lactam antibiotic is extremely active towards bacteria. Penicillins are also termed as penams. It is naturally occurring and has a bicyclic skeleton. Streptomycin is a pseudotrisaccharide. It comprises of a monosubstituted aminocyclitol.
Application
Recommended for use in cell culture media at 20 ml/L.
Penicillin-Streptomycin has been used:
- as a supplement in Dulbecco′s modified Eagle′s medium (DMEM) to maintain the Huh7 liver hepatoma cell line
- as a supplement in Roswell park memorial institute-1640 (RPMI) medium to maintain mouse lymphoma YAC-1 cells
- as a component in minimum essential medium Eagle to treat individual mouse spleens for the preparation of splenocytes
- as a supplement in FMX-8 complete medium to culture Chinese hamster ovary cells[1]
Biochem/physiol Actions
Penicillins can prevent the synthesis of bacterial cell wall. This antibiotic can be used in the treatment of skin and urinary tract infections, upper and lower respiratory infections, and endocarditis. Streptomycin can block Mycobacterium tuberculosis in vitro. Streptomycin inhibits prokaryote protein synthesis[1] by preventing the transition from initiation complex to chain-elongating ribosome, causing miscoding.
Other Notes
20ml,100ml
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
This product is formulated to contain 5,000 units penicillin and 5 mg streptomycin/mL solubilized in a proprietary citrate buffer.
1 of 1
This Item | |||
|---|---|---|---|
| technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable |
| antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum Gram-positive bacteria | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria |
| mode of action protein synthesis | interferes, cell wall synthesis | interferes | mode of action cell wall synthesis | interferes, protein synthesis | interferes | mode of action cell wall synthesis | interferes | mode of action cell wall synthesis | interferes, protein synthesis | interferes |
| product line BioReagent | product line BioReagent | product line BioReagent | product line - |
| Quality Level 300 | Quality Level 300 | Quality Level 200 | Quality Level - |
| form liquid | form liquid | form powder | form lyophilized (clear, colorless solution after reconstitution) |
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| P4458-20ML | 04061834374626 |
| P4458-100ML | 04061834374619 |
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What is the Department of Transportation shipping information for this product?
1 answer-
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What is the concentration of the P4458 Penicillin-Streptomycin solution? For example, is it a 50X or 100X?
1 answer-
Product No. P4458 is designed to be added directly to media; you should add 20mL to 1L of medium. There is no intermediate dilution step. So the concentration 50X refers to the 50X dilution into media to the final working concentration.
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What is the method of preparation for Product No. P4458 (Penicillin-Streptomycin); what solution is it made in?
1 answer-
Product No. P4458 is not simply penicillin and streptomycin dissolved in water; it is made in a proprietary buffer.
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What is the storage temperature and the stability of the P4458 Penicillin-Streptomycin?
1 answer-
Product No. P4458 (Penicillin-Streptomycin solution) should be stored in the freezer at -20 °C for long-term storage. It may be kept refrigerated at 2-8 °C for up to 40 days.
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