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Anti-Podoplanin antibody produced in rabbit

Name: Anti-Podoplanin antibody produced in rabbit
Brand: SIGMA
Price: 636 USD
Availability: InStock

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Aggrus, Anti-GP36, Anti-Glycoprotein, 36-KD, Anti-OTS8, Anti-T1α gene, Anti-T1A, Anti-T1A2

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Size/SKU	Availability	Price
200 μL	Check Cart for Availability	$636.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD09265367

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IHC (p), WB CL

Citations:

$636.00

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~38 kDa

species reactivity

human, rat

concentration

~1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 10-20 μg/mL using heat retrieved, human skin sections, western blot (chemiluminescent): 5-10 μg/mL using human HEK-293 or rat NRK cells

UniProt accession no.

Q86YL7

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PDPN(10630)
rat ... Pdpn(54320)

Description

General description

Podoplanin (PDPN) is a transmembrane sialoglycoprotein. It consists of 162 amino acids and is part of the type-1 transmembrane sialomucin-like glycoprotein family. The protein is expressed in various tissues. The PDPN gene is localized on human chromosome 1p36.21.

Podoplanin is an integral membrane mucoprotein present on the surface of podocytes in kidney glomeruli and the parietal cells of the glomerular Bowman′s capsule. It is a single membrane-spanning protein composed of a heavily glycosylated extracellular domain and a short intracytoplasmic tail. Podoplanin, also named E11 antigen, is present in normal, inflammatory and neoplastic lymphatic capillary endothelium. It is expressed selectively by dermal microvascular lymphatic endothelial cells but not by blood vascular endothelial cells.

Immunogen

synthetic peptide corresponding to amino acids 24-40 of human podoplanin with an N-terminal added cysteine, conjugated to KLH.

Application

Anti-Podoplanin antibody produced in rabbit has been used in immunohistochemistry.

Anti-Podoplanin antibody produced in rabbit has been used in immunoblotting.

Biochem/physiol Actions

Podoplanin (PDPN) is expressed in many cancers. In cancerous cells, it induces platelet aggregation and epithelial-mesenchymal transition. The protein is an immunohistochemical marker of lymphatic vessels. Podoplanin also has a role in embryonic development.

Podoplanin appears to play an important role in the maintenance of podocyte foot processes, and hence, glomerular permeability. It is detectable in human angiosarcomas, lymphangiomas and in Kaposi′s sarcomas. Experiments involving depletion of T1a/podoplanin in mice indicate a critical regulatory role for it in formation of the lymphatic vasculature.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide and 1% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	P0085	MABC117	SAB5702683
Sigma-Aldrich P5374 Anti-Podoplanin antibody produced in rabbit	Sigma-Aldrich P0085 Anti-Podoplanin antibody, RAT monoclonal	Sigma-Aldrich MABC117 Anti-Podoplanin Antibody, clone NZ1.2	Sigma-Aldrich SAB5702683 Anti-Podoplanin Antibody, clone 8I3I5, Rabbit Monoclonal
description ~1 mg/mL, affinity isolated antibody, buffered aqueous solution	description clone NZ-1.2, purified from hybridoma cell culture	description clone NZ1.2, from rat	description -
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
biological source rabbit	biological source rat	biological source rat	biological source rabbit
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 100
antibody form affinity isolated antibody	antibody form purified from hybridoma cell culture	antibody form purified antibody	antibody form -
UniProt accession no. Q86YL7	UniProt accession no. Q86YL7	UniProt accession no. Q86YL7	UniProt accession no. Q86YL7
clone polyclonal	clone NZ-1.2, monoclonal	clone NZ1.2, monoclonal	clone 8I3I5, monoclonal

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Storage Class

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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