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Anti-Platelet-Derived Growth Factor antibody produced in goat

Name: Anti-Platelet-Derived Growth Factor antibody produced in goat
Brand: SIGMA
Price: 570 USD
Availability: InStock

IgG fraction of antiserum, lyophilized powder

Synonym(s):

Anti-PDGF

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Size/SKU	Availability	Price
1 mg	Available to ship TODAYfromMILWAUKEE	$570.00

About This Item

UNSPSC Code:

51111800

NACRES:

NA.41

MDL number:

MFCD00165456

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA (i), Neutral, WB

Citations:

$570.00

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Properties

biological source

goat

Quality Segment

100

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human

technique(s)

indirect ELISA: suitable, neutralization: suitable, western blot: suitable

UniProt accession no.

P01127, P04085

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PDGFA(5154), PDGFB(5155)

Description

General description

Platelet-derived growth factor (PDGF) is a serum growth factor purified from human platelets. The members of PDGF are homodimers of A-, B-, C- and –D polypeptide chains and an AB heterodimer. PDGF is a mitogen and stimulates the proliferation of cells of connective tissue and glial cells, survival, differentiation, chemotaxis and wound healing. The cellular effects of PDGF isoforms are mediated by binding to α- and β-receptors which leads to activation of downstream signaling via PI3K, STAT and Ras/MAPK. Overexpression of PDGF isoforms has been observed in various malignancies including gliomas, osetosarcoma, chronic myelomonocytic leukemia and non-small-cell lung cancers
Anti-Human Platelet-Derived Growth Factor (PDGF) specifically recognizes natural human PDGF. It will also neutralize the activity of recombinant human PDGF-AB, recombinant human PDGF-AA, recombinant human PDGF-BB, and natural porcine PDGF-BB. It shows cross reactivity with recombinant human PDGF-AB, recombinant human PDGF-AA, recombinant human PDGF-BB, and natural porcine PDGF-BB.

Immunogen

natural human PDGF.

Application

Anti-Human Platelet-Derived Growth Factor (PDGF) antibody may be used for ELISA at a working concentration of 0.25 μg/ml. The antibody has been used for ELISA at a dilution of 1:500 using human serum.. For immunoblotting, a concentration of 1 μg/ml is recommended. The antibody is suitable for neutralization reactions and has been used to neutralize PDGF of primary Human dermal fibroblasts (HDFs) and human platelet-enriched plasma.

Biochem/physiol Actions

The antibody will neutralize the biological activity of natural human PDGF, recombinant human PDGF-AB, PDGF-AA and PDGF-BB and natural porcine PDGF-BB.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline (pH 7.4) with 5% trehalose.

Preparation Note

Purified using protein G.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Show Differences

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This Item	P3326	P3201	P5976
$Anti-Platelet-Derived Growth Factor antibody produced in goat IgG fraction of antiserum, lyophilized powder$ Sigma-Aldrich P6101 Anti-Platelet-Derived Growth Factor antibody produced in goat	Sigma-Aldrich P3326 Platelet-Derived Growth Factor-AB human	Sigma-Aldrich P3201 Platelet-Derived Growth Factor-BB human	Sigma-Aldrich P5976 Anti-Platelet-Derived Growth Factor-BB antibody produced in goat
description IgG fraction of antiserum, lyophilized powder	description PDGF-AB, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture	description PDGF-BB, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture	description affinity isolated antibody, lyophilized powder
Quality Level 100	Quality Level 200	Quality Level 200	Quality Level 100
antibody form IgG fraction of antiserum	antibody form -	antibody form -	antibody form affinity isolated antibody
biological source goat	biological source human	biological source human	biological source goat
conjugate unconjugated	conjugate -	conjugate -	conjugate unconjugated
species reactivity human	species reactivity -	species reactivity -	species reactivity human
form lyophilized powder	form lyophilized powder	form lyophilized powder	form lyophilized powder

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Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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