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P9115

Protein Kinase A inhibitor fragment 14-22, myristoylated trifluoroacetate salt

≥90% (HPLC), lyophilized powder

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Size/SKUAvailabilityPrice
1 mg

Estimated to ship TODAYfromMILWAUKEE

$406.00

About This Item

Empirical Formula (Hill Notation):
C53H98N20O12 · C2HF3O2
Molecular Weight:
1321.50
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352204
MDL number:

$406.00


Estimated to ship TODAYDetails


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Quality Segment

assay

≥90% (HPLC)

form

lyophilized powder

solubility

H2O: soluble

storage temp.

−20°C

SMILES string

OC(=O)C(F)(F)F.CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O

InChI

1S/C53H100N20O12.C2HF3O2/c1-6-8-9-10-11-12-13-14-15-16-17-24-39(76)65-29-40(77)69-35(22-19-26-63-52(58)59)48(83)73-43(33(5)74)50(85)66-30-41(78)68-34(21-18-25-62-51(56)57)46(81)70-36(23-20-27-64-53(60)61)47(82)71-37(28-38(54)75)49(84)67-32(4)45(80)72-42(44(55)79)31(3)7-2;3-2(4,5)1(6)7/h31-37,42-43,74H,6-30H2,1-5H3,(H2,54,75)(H2,55,79)(H,65,76)(H,66,85)(H,67,84)(H,68,78)(H,69,77)(H,70,81)(H,71,82)(H,72,80)(H,73,83)(H4,56,57,62)(H4,58,59,63)(H4,60,61,64);(H,6,7)/t31-,32-,33+,34-,35-,36-,37-,42-,43-;/m0./s1

InChI key

DBHNUJXUTKVLID-UXBYPZMDSA-N

Gene Information

human ... PRKACA(5566)
mouse ... PRKACA(18747)
rat ... PRKACA(25636)

General description

Protein kinase A inhibitor fragment 14-22, myristoylated trifluoroacetate salt inhibits the protein kinase cAMP-activated catalytic subunit-α (PRKACA). The gene encoding it is localized on human chromosome 19p13.1.

Application

Protein kinase A inhibitor fragment 14-22, myristoylated trifluoroacetate salt has been used in cell culture for pharmaceutical inhibition and activation studies.

Biochem/physiol Actions

Mutations in the gene encoding protein kinase cAMP-activated catalytic subunit-α (PRKACA) have been associated with Cushing′s syndrome.
Cell permeable cAMP-dependent protein kinase (PKA) inhibitor

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This Item
P7739P6998476485
description

≥90% (HPLC), lyophilized powder

description

≥95% (HPLC), lyophilized powder

description

recombinant, expressed in baculovirus infected Sf9 cells, ≥80% (SDS-PAGE), buffered aqueous glycerol solution

description

PKA Inhibitor 14-22 Amide is myristoylated at the N-terminus that enhances its cell-permeability. The non-myristoylated version is shown to be a specific inhibitor of PKA (Ki = 36 nM).

assay

≥90% (HPLC)

assay

≥95% (HPLC)

assay

≥80% (SDS-PAGE)

assay

≥95% (HPLC)

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

100

form

lyophilized powder

form

lyophilized powder

form

buffered aqueous glycerol solution

form

lyophilized

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−70°C

storage temp.

−20°C

Gene Information

human ... PRKACA(5566)
mouse ... PRKACA(18747)
rat ... PRKACA(25636)

Gene Information

human ... PKIA(5569)

Gene Information

human ... PRKACB(5567)

Gene Information

-

solubility

H2O: soluble

solubility

H2O: soluble

solubility

-

solubility

water: 1 mg/mL


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)



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