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R125

Anti-RANTES antibody produced in goat

affinity isolated antibody, lyophilized powder

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Size/SKUAvailabilityPrice
100 μg

Available to ship TODAYfromMILWAUKEE

$696.00

About This Item

UNSPSC Code:
51111800
NACRES:
NA.41
MDL number:
MFCD00213043
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC (f), Neutral, WB
Citations:
8

$696.00

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biological source

goat

Quality Segment

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human

technique(s)

immunohistochemistry (frozen sections): suitable, neutralization: suitable, western blot: suitable

UniProt accession no.

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CCL5(6352)

General description

RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted; CCL5) is a chemokine that brings T cells, monocytes, eosinophils, NK cells, dendritic cells and mast cells to the site of infection or inflammation. RANTES has an unusual kinetic profile and is secreted 3-5 days after the activation of the T cells. It also exhibits antimicrobial activity by inducing the production of nitric oxide in macrophages. The main function of RANTES is mediated by CCR5, CCR1, CCR3 and other receptors. The expression of RANTES is regulated mainly by JAK/STAT and NF-κB pathways. Polymorphisms in the gene encoding RANTES are implicated in artherosclerosis, multiple sclerosis, HIV infection, diabetes, inflammatory diseases of the lung, renal disease and systemic lupus erythematosus. In addition, RANTES is a potential prognostic factor to track the progression of stage II breast cancer
Anti-RANTES antibody specifically recognizes human RANTES. The antibody shows ~40% cross-reactivity with mouse RANTES and canine RANTES, ~20% cross-reactivity with cotton rat RANTES, and ~1% cross-reactivity with feline RANTES.

Immunogen

recombinant human RANTES expressed in E. coli.

Application

Anti-RANTES antibody may be used for immunoblotting at a working concentration of 0.1 μg/ml. For immunohistochemistry and immunofluorescence, a working concentration of 5-15 μg/ml may be used. The antibody is suitable for neutralization reactions (ND50 is 0.1-0.4 μg/ml).

Biochem/physiol Actions

Based on ELISA, the antibody shows ~40% cross-reactivity with recombinant mouse RANTES, ~20% cross-reactivity with recombinant cotton rat RANTES, and ~1% cross-reactivity with recombinant feline RANTES.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item
R6267SRP3269GF311
Anti-RANTES antibody produced in goat affinity isolated antibody, lyophilized powder

Sigma-Aldrich

R125

Anti-RANTES antibody produced in goat

RANTES human ≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sigma-Aldrich

R6267

RANTES human

RANTES human Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

Sigma-Aldrich

SRP3269

RANTES human

RANTES Protein, Human Recombinant Animal Free

Sigma-Aldrich

GF311

RANTES Protein, Human Recombinant Animal Free

description

affinity isolated antibody, lyophilized powder

description

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

description

Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

description

-

conjugate

unconjugated

conjugate

-

conjugate

-

conjugate

-

antibody form

affinity isolated antibody

antibody form

-

antibody form

-

antibody form

-

Quality Level

200

Quality Level

100

Quality Level

-

Quality Level

300

biological source

goat

biological source

human

biological source

human

biological source

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

species reactivity

human

species reactivity

-

species reactivity

-

species reactivity

-

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Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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