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R1903

RS 102895 hydrochloride

≥98% (HPLC), powder

Synonym(s):

1′-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4′-peperidin]-2(1H)-one

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAY

$274.00

About This Item

Empirical Formula (Hill Notation):
C21H21F3N2O2 · HCl
Molecular Weight:
426.86
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:

$274.00


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Quality Segment

assay

≥98% (HPLC)

form

powder

mol wt

426.86 g/mol

packaging

pkg of 5 mg

storage condition

desiccated

color

white

solubility

DMSO: >10 mg/mL

storage temp.

20-25°C

SMILES string

Cl.FC(F)(F)c1ccc(CCN2CCC3(CC2)OC(=O)Nc4ccccc34)cc1

InChI

1S/C21H21F3N2O2.ClH/c22-21(23,24)16-7-5-15(6-8-16)9-12-26-13-10-20(11-14-26)17-3-1-2-4-18(17)25-19(27)28-20;/h1-8H,9-14H2,(H,25,27);1H

InChI key

KRRISOFSWVKYBF-UHFFFAOYSA-N

General description

RS 102895 hydrochloride is a small molecule antagonist of C-C motif chemokine receptor 2 (CCR2) which belongs to the spiropiperidine (SP) class.

Application

RS 102895 hydrochloride has been used in bromodeoxyuridine (5-bromo-2′-deoxyuridine, BrdU) cell proliferation assay to study effect of IL33 (interleukin 33) on decidual stromal cell proliferation in present of the antagonist and to study the effects of antagonists on the accumulation of bone marrow-derived microglia.

Biochem/physiol Actions

RS 102895 hydrochloride has a high affinity to the β subunit of the C-C motif chemokine receptor 2 (CCR2) and binds specifically to it. This results in the inhibition of CCR2 signaling. It also suppresses monocyte recruitment. Hence, RS 102895 may be useful for obstructing the immune suppressive effects of monocytes during early vaccine responses.

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This Item
227016R2533
description

≥98% (HPLC), powder

description

The CCR2 Antagonist, also referenced under CAS 445479-97-0, controls the biological activity of CCR2.

description

≥98% (HPLC), powder

assay

≥98% (HPLC)

assay

≥97% (racemic mixture, HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

form

powder

form

solid

form

powder

mol wt

426.86 g/mol

mol wt

-

mol wt

-

storage condition

desiccated

storage condition

OK to freeze, protect from light, desiccated (hygroscopic)

storage condition

desiccated

storage temp.

20-25°C

storage temp.

2-8°C

storage temp.

2-8°C


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)



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