The solubility of the product in medium or aqueous buffers has not been determined as the compound is only sparingly soluble in aqueous solutions. Concentrated stock solutions can be made in DMSO up to 100 mg/mL. Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C. Stock solutions can be further diluted in the buffer or medium of choice. Diluted working solutions should be prepared fresh and not stored for more than 1 day.
R2408
Rosiglitazone
≥98% (HPLC), powder, PPARγ agonist
Synonym(s):
Rosiglitazone, 5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione
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| Size/SKU | Availability | Price |
|---|---|---|
10 mg | Available to ship TODAYfromMILWAUKEE | $105.00 |
50 mg | Available to ship TODAYfromMILWAUKEE | $428.00 |
About This Item
Linear Formula:
C18H19N3O3S
CAS Number:
Molecular Weight:
357.43
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Product Name
Rosiglitazone,
assay
≥98% (HPLC)
Quality Segment
form
powder
solubility
DMSO: ≥10 mg/mL
originator
GlaxoSmithKline
storage temp.
2-8°C
SMILES string
CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c3ccccn3
InChI
1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,15H,10-12H2,1H3,(H,20,22,23)
InChI key
YASAKCUCGLMORW-UHFFFAOYSA-N
Gene Information
human ... PPARG(5468)
General description
Rosiglitazone is a member of the thiazolidinedione family. It effectively lowers glucose levels by enhancing the response of target cells to insulin, without causing increased stimulation and release of insulin by the pancreatic beta cells. Rosiglitazone functions by activating the nuclear peroxisome proliferator-activated (PPAR) receptor gamma, which plays a key role in regulating adipogenesis, glucose metabolism, and genetic networks. It exhibits high potency as a thiazolidinedione, with a binding affinity for PPAR-gamma that is 30-fold higher than pioglitazone. Furthermore, it increases insulin-stimulated IRS-1/2 in skeletal muscle and adipose tissue, leading to the expression of the GLUT4 glucose transporter.
Application
Rosiglitazone has been used:
- as a medium constituent for adipocyte differentiation
- in the cell proliferation assay in human colonic carcinoma cell lines
- for Bcl-2-like protein 13 (Bcl2l13) expression in adipocytes
- as a peroxisome proliferator-activated receptor gamma (PPARγ) ligand
Biochem/physiol Actions
Potent agonist for PPARγ with an EC50 of 43 nM for the human receptor.
Rosiglitazone is a potent agonist for PPARγ with an EC50 of 43 nM for the human receptor. It is antidiabetic, working as an insulin sensitizer by binding to the PPARγ receptors in fat cells and making the cells more responsive to insulin.
Features and Benefits
This compound is a featured product for ADME Tox and Gene Regulation research. Discover more featured ADME Tox and Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the AMPKs and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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This Item | |||
|---|---|---|---|
| description - | description Pharmaceutical Secondary Standard; Certified Reference Material | description ≥98% (HPLC) | description ≥98% (HPLC) |
| assay ≥98% (HPLC) | assay - | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form powder | form solid | form powder | form powder |
| Quality Level 100 | Quality Level 300 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: ≥10 mg/mL | solubility - | solubility DMSO: 10 mg/mL, clear (warmed) | solubility DMSO: 10 mg/mL, clear |
| originator GlaxoSmithKline | originator - | originator - | originator - |
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Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral
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Can the material be dissolved in DMEM/F-12 as well?
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