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RANTES human

Name: RANTES human
Brand: SIGMA
Price: 395 USD
Availability: InStock

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(s):

Regulated on Activation, Normal T-cell Expressed and Secreted

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Size/SKU	Availability	Price
10 μg	Available to ship TODAYfromMILWAUKEE	$381.00 $395.00

About This Item

UNSPSC Code:

12352202

EC Number:

200-835-2

NACRES:

NA.32

MDL number:

MFCD00213042

$395.00

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Properties

biological source

human

Quality Segment

100

recombinant

expressed in E. coli

assay

≥97% (SDS-PAGE)

form

lyophilized powder

potency

1-5 ng/mL EC₅₀

mol wt

7.8-8.7 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

P13501

storage temp.

−20°C

Gene Information

human ... CCL5(6352)

Description

General description

Regulated on activation, normal T cell expressed and secreted (RANTES), also known as C-C motif chemokine ligand 5 (CCL5), is encoded by the gene mapped to human chromosome 17. RANTES belongs to the chemokine family of proinflammatory basic polypeptides and is expressed by various hematopoietic and non-hematopoietic cell types involved in homing and migration of effector and memory T cells during acute infections.

Biochem/physiol Actions

Regulated on activation, normal T cell expressed and secreted (RANTES) is a chemoattractant towards monocytes, dendritic cells (DCs), memory T cells (CD4⁺/CD45RO), basophils, and eosinophils. The encoded chemokine protein functions as a ligand for CCR1, CCR3, and CCR5. RANTES inhibits the action of R5 strains of HIV-1 via blocking CCR5 receptor. A variant of RANTES gene is linked with susceptibility to HIV-1 infection and disease progression. Hence, this can be used as a potent biomarker to determine the prognosis of HIV -1 infection.

Physical form

Lyophilized from a 0.2 μm filtered solution in 35% acetonitrile and 0.1% trifluoroacetic acid containing 0.5 mg bovine serum albumin.

Analysis Note

The biological activity is tested in culture using Baf/3 cells. Chemotaxis: EC₅₀: 1-5 ng/mL

Disclaimer

Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.

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This Item	SRP3269	R125	GF311
Sigma-Aldrich R6267 RANTES human	Sigma-Aldrich SRP3269 RANTES human	Sigma-Aldrich R125 Anti-RANTES antibody produced in goat	Sigma-Aldrich GF311 RANTES Protein, Human Recombinant Animal Free
description ≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture	description Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)	description affinity isolated antibody, lyophilized powder	description -
technique(s) cell culture \| mammalian: suitable	technique(s) -	technique(s) immunohistochemistry (frozen sections): suitable, neutralization: suitable, western blot: suitable	technique(s) -
assay ≥97% (SDS-PAGE)	assay ≥98% (HPLC), ≥98% (SDS-PAGE)	assay -	assay >98% (SDS-PAGE)
biological source human	biological source human	biological source goat	biological source -
recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant -	recombinant -
Quality Level 100	Quality Level -	Quality Level 200	Quality Level 300
form lyophilized powder	form lyophilized	form lyophilized powder	form -

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Pictograms

GHS02,GHS07

Signal Word

Danger

Hazard Codes

H225,H302 + H312 + H332,H319

Precautionary Statements

P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class

3 - Flammable liquids

WGK

WGK 2

Flash Point (°F)

35.6 °F

Flash Point (°C)

2 °C

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