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R7752

Ristomycin monosulfate

≥90% ristocetin A basis (balance primarily Ristocetin B), powder, platelet activator

Synonyme(s) :

Ristocetin sulfate salt

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100 mg
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974,00 $
250 mg
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A propos de cet article

Formule empirique (notation de Hill) :
C95H110N8O44 · H2SO4
Numéro CAS:
11140-99-1
Poids moléculaire :
2166.00
UNSPSC Code:
12352202
PubChem Substance ID:
24899399
NACRES:
NA.77
MDL number:
MFCD00076121
Assay:
≥90% ristocetin A basis (balance primarily Ristocetin B)
Quality level:
200

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Nom du produit

Ristomycin monosulfate, ≥90% ristocetin A basis (balance primarily Ristocetin B)

Quality Level

200

assay

≥90% ristocetin A basis (balance primarily Ristocetin B)

mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

SMILES string

COC(=O)[C@@H]1NC(=O)[C@H]2NC(=O)C(NC(=O)[C@@H]3NC(=O)[C@H]4NC(=O)[C@H](NC(=O)[C@H](N)c5ccc(O)c(Oc6cc4cc(O)c6C)c5)[C@H](O)c7ccc(Oc8cc3cc(Oc9ccc(cc9)[C@H]2O[C@H]%10C[C@@H](N)[C@@H](O)[C@H](C)O%10)c8O[C@@H]%11O[C@H](CO[C@@H]%12O[C@@H](C)[C@H](O)[C@@H](O)[C@H]%12O)[C@@H](O)[C@H](O)[C@H]%11O[C@H]%13O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%13O[C@@H]%14OC[C@@H](O)[C@@H](O)[C@@H]%14O)cc7)c%15ccc(O)c(c%15)-c%16c(O[C@@H]%17O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]%17O)cc(O)cc1%16

InChI

1S/C95H110N8O44/c1-30-47(109)18-37-20-49(30)139-50-19-35(9-16-46(50)108)59(97)84(125)102-64-68(113)33-5-11-40(12-6-33)137-52-21-38-22-53(81(52)145-95-83(76(121)72(117)56(143-95)29-134-91-78(123)73(118)67(112)32(3)136-91)147-94-82(75(120)71(116)55(27-105)142-94)146-92-77(122)69(114)48(110)28-133-92)138-41-13-7-34(8-14-41)80(144-57-25-44(96)66(111)31(2)135-57)65-89(130)101-63(90(131)132-4)43-23-39(106)24-51(140-93-79(124)74(119)70(115)54(26-104)141-93)58(43)42-17-36(10-15-45(42)107)60(85(126)103-65)98-87(128)62(38)99-86(127)61(37)100-88(64)129/h5-24,31-32,44,48,54-57,59-80,82-83,91-95,104-124H,25-29,96-97H2,1-4H3,(H,98,128)(H,99,127)(H,100,129)(H,101,130)(H,102,125)(H,103,126)/t31-,32-,44+,48+,54+,55+,56+,57-,59+,60?,61-,62+,63?,64+,65-,66-,67-,68+,69+,70+,71+,72+,73+,74-,75-,76-,77-,78+,79-,80+,82-,83+,91+,92-,93+,94+,95-/m0/s1

InChI key

VUOPFFVAZTUEGW-ZNAZZOOYSA-N

General description

Ristomycin/ristocetin is a type III glycopeptide. It is a highly glycosylated glycopeptide, previously found in Amycolatopsis lurida.[1]

Application

Ristomycin monosulfate has been used:
  • to activate platelet and induce platelet aggregation
  • to study the aggregation responses of platelets from buffalo, horse, pig and sheep
  • in in-house ristocetin cofactor von Willebrand factor (VWF:RCo) assay to measure glycoprotein Ib (GpIb) binding activity

Biochem/physiol Actions

Ristomycin possesses antibacterial activity. It may be used to diagnose von Willebrand disease and Bernard-Soulier syndrome.[1] Ristocetin-induced platelet agglutination (RIPA) is decreased in patients undergoing chronic hemodialysis. Increased plasma glycocalicin levels (a product of enzymatic cleavage of GPIb) and decreased RIPA might reduce platelet adhesion to vascular subendothelium and improve bleeding associated with uremia in patients with chronic hemodialysis.
Ristocetin activates platelets. Ristocetin-induced platelet agglutination (RIPA) is decreased in patients undergoing chronic hemodialysis. Together with increased plasma glycocalicin levels (a product of enzymatic cleavage of GPIb), RIPA may contribute to diminished platelet adhesion to vascular subendothelium and increased bleeding associated with uremia. Addition of ristocetin and vWf caused specific agglutination of rGPIbα-liposomes suporting the potential use of rGPIbα-liposomes to enhance platelet function in vivo and support hemostasis in thrombocytopenic individuals.

Other Notes

Glycopeptide antibiotic complex

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Cet article
V8388M0440M4287
Ristomycin monosulfate ≥90% ristocetin A basis (balance primarily Ristocetin B)

Sigma-Aldrich

R7752

Ristomycin monosulfate

Vincristine sulfate meets USP testing specifications

Sigma-Aldrich

V8388

Vincristine sulfate

Mitomycin C from Streptomyces caespitosus meets USP testing specifications

Sigma-Aldrich

M0440

Mitomycin C from Streptomyces caespitosus

Mitomycin C from Streptomyces caespitosus powder, BioReagent, suitable for cell culture

Sigma-Aldrich

M4287

Mitomycin C from Streptomyces caespitosus

assay

≥90% ristocetin A basis (balance primarily Ristocetin B)

assay

-

assay

-

assay

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

mode of action

cell wall synthesis | interferes

mode of action

protein synthesis | interferes

mode of action

DNA synthesis | interferes

mode of action

DNA synthesis | interferes

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
0000530062
0000523855
0000523855
0000530062
0000446969

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Articles

Bioactive Molecules for Immunology Research

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

Jordan, D.C. et al.
Antibiotics, 1, 84-84 (1967)
Elevated plasma glycocalicin levels and decreased ristocetin-induced platelet agglutination in hemodialysis patients
Himmelfarb J, et al.
American Journal of Kidney Diseases, 32(1), 132-138 (1998)
A Kasirer-Friede et al.
Thrombosis and haemostasis, 80(3), 428-436 (1998-10-06)
We recently reported that washed platelets (WP) activated with ADP and expressing surface-bound vWF aggregated in flow through small tubes or in a cylindrical couette device at physiological shear rates of G = 300 s(-1)-1000 s(-1) in the absence of
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Numéro d'article de commerce international

RéférenceGTIN
R7752-250MG04061836696740
R7752-100MG04061836696726

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