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Anti-Rab7 antibody, Mouse monoclonal

Name: Anti-Rab7 antibody, Mouse monoclonal
Brand: SIGMA
Price: 192 USD
Availability: InStock

~2 mg/mL, clone Rab7-117, purified from hybridoma cell culture

Synonym(s):

Anti-Ras-associated protein

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Size/SKU	Availability	Price
25 μL	Check Cart for Availability	$192.00
100 μL	Check Cart for Availability	$552.00 $469.20
200 μL	Check Cart for Availability	$727.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD08705596

Conjugate:

unconjugated

Clone:

Rab7-117, monoclonal

Application:

ARR, ELISA (i), ICC, IP, WB

Citations:

$192.00

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Properties

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

Rab7-117, monoclonal

form

buffered aqueous solution

mol wt

~24 kDa

species reactivity

bovine, human, monkey, mouse, chicken, rat

packaging

antibody small pack of 25 μL

concentration

~2 mg/mL

technique(s)

immunocytochemistry: suitable, immunoprecipitation (IP): suitable, indirect ELISA: suitable, microarray: suitable, western blot: 0.5-1 μg/mL using HeLa total cell extract

isotype

IgG2b

UniProt accession no.

P51149

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RAB7A(7879)
mouse ... Rab7(19349)
rat ... Rab7a(29448)

Description

General description

Rab7 is a member of the Rab family of small guanosine triphosphatases (GTPases). This family belongs to the rat sarcoma (Ras) superfamily of small GTPases. Rab proteins contain conserved regions involved in guanine nucleotide binding and hypervariable COOH-terminal domains with a cysteine motif, implicated in subcellular targeting. Post-translational modification of the cysteine motif with one or two geranylgeranyl groups is essential for the membrane association and correct intracellular localization of Rab proteins. The gene Rab7a in human chromosome is mapped to 3q21.3.

Application

Monoclonal Anti-Rab7 antibody produced in mouse may be used in ELISA, immunoblotting (~24 kDa), immunoprecipitation, immunohistochemistry, immunofluorescence and immunocytochemistry.

Biochem/physiol Actions

Monoclonal Anti-Rab7 recognizes human, monkey, bovine, rat, mouse, and chicken Rab7.

Rab GTPases are central regulators of membrane trafficking between different subcellular compartments in eukaryotic cells. The regulatory capacity of Rab GTPases depends on their ability to cycle between the GDP-bound inactive and GTP-bound active states. Activation of Rab proteins is coupled to their association with intracellular membranes, allowing them to recruit downstream effector proteins to the cytoplasmic surface of a subcellular compartment. Through their effector proteins, Rab GTPases regulate vesicle formation, actin and tubulin-dependent vesicle movement, and membrane fusion. Rab7 regulates vesicle traffic from early to late endosomes, and from late endosomes to lysosomes. Rab7 is also involved in the maturation of late autophagic vacuoles. Among Rab7 effectors are Rab-interacting lysosome protein (RILP) that controls late endosomal and lysosomal transport by mediating the recruitment of dynein/dynactin motors, Rab-7-interacting ring finger protein (Rabring7) and the hVPS34/p150 complex.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Show Differences

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This Item	R4779	R7904	HPA006964
Sigma-Aldrich R8779 Anti-Rab7 antibody, Mouse monoclonal	Sigma-Aldrich R4779 Anti-Rab7 antibody produced in rabbit	Sigma-Aldrich R7904 Anti-Rab5 antibody, Mouse monoclonal	Sigma-Aldrich HPA006964 Anti-RAB7A antibody produced in rabbit
description ~2 mg/mL, clone Rab7-117, purified from hybridoma cell culture	description affinity isolated antibody, buffered aqueous solution	description clone Rab5-65, purified from hybridoma cell culture	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
antibody form purified from hybridoma cell culture	antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form affinity isolated antibody
Gene Information human ... RAB7A(7879) mouse ... Rab7(19349) rat ... Rab7a(29448)	Gene Information human ... RAB7A(7879) mouse ... Rab7(19349) rat ... Rab7a(29448)	Gene Information human ... RAB5A(5868) mouse ... Rab5a(271457) rat ... Rab5a(64633)	Gene Information human ... RAB7A(7879)
clone Rab7-117, monoclonal	clone polyclonal	clone Rab5-65, monoclonal	clone polyclonal
biological source mouse	biological source rabbit	biological source mouse	biological source rabbit
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
species reactivity bovine, human, monkey, mouse, chicken, rat	species reactivity mouse, human, rat	species reactivity human, cat, bovine, mouse, rat	species reactivity mouse, human, rat

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

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