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R9644

Ribavirin

≥98% (TLC), IMP dehydrogenase inhibitor, powder

Synonym(s):

1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide

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Size/SKUAvailabilityPrice
10 mg

Available to ship TODAYfromMILWAUKEE

$66.50
50 mg

Available to ship TODAYfromMILWAUKEE

$237.00

About This Item

Empirical Formula (Hill Notation):
C8H12N4O5
CAS Number:
Molecular Weight:
244.20
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
MDL number:

$66.50


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Product Name

Ribavirin, antiviral

Quality Segment

assay

≥98% (TLC)

form

powder

solubility

water: 19.60-20.40 mg/mL, clear, colorless to faintly yellow

antibiotic activity spectrum

viruses

mode of action

DNA synthesis | interferes

storage temp.

2-8°C

SMILES string

NC(=O)c1ncn(n1)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O

InChI

1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1

InChI key

IWUCXVSUMQZMFG-AFCXAGJDSA-N

Gene Information

General description

Analog of the imidazole nucleotide intermediates in purine nucleotide biosynthesis.
Chemical structure: nucleoside

Biochem/physiol Actions

Antiviral agent used against a wide variety of human viral infections, in particular, chronic hepatitis C, HIV, and adenovirus. Its metabolite, ribavirin 5′-phosphate, is an inhibitor of inosine monophosphate (IMP) dehydrogenase, but many other mechanisms of action are also supported with experimental evidence.
Antiviral agent used against a wide variety of human viral infections, in particular, chronic hepatitis C, HIV, and adenovirus. Its metabolite, ribavirin 5′-phosphate, is an inhibitor of inosine monophosphate (IMP) dehydrogenase.
Antiviral agent. Its metabolite, ribavirin 5′-phosphate, is an inhibitor of inosine monophosphate (IMP) dehydrogenase. Used to inhibit purine (GTP pools) biosynthesis at the level of inosine monophosphate (IMP) dehydrogenase and as a precursor to the di- and tri-phosphates which inhibit viral RNA-dependent RNA polymerases.

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This Item
555580BP593PHR1700
Ribavirin British Pharmacopoeia (BP) Reference Standard

BP593

Ribavirin

description

antiviral

description

A non-interferon-inducing, broad spectrum antiviral nucleoside. Reported to be active against RSV, HIV, HCV, and other infectious agents. Its metabolite, ribavirin-5′-phosphate, inhibits inosine monophosphate (IMP) dehydrogenase.

description

British Pharmacopoeia (BP) Reference Standard

description

Pharmaceutical Secondary Standard; Certified Reference Material

assay

≥98% (TLC)

assay

≥99% (HPLC), ≥99% (TLC)

assay

-

assay

-

Gene Information

human ... IMPDH1(3614), IMPDH2(3615)

Gene Information

-

Gene Information

human ... IMPDH1(3614)

Gene Information

human ... IMPDH1(3614)

Quality Level

200

Quality Level

100

Quality Level

-

Quality Level

300

form

powder

form

solid

form

solid

form

-

storage temp.

2-8°C

storage temp.

15-25°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

water: 19.60-20.40 mg/mL, clear, colorless to faintly yellow

solubility

water: 20 mg/mL, DMSO: soluble

solubility

-

solubility

-


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Pictograms

Health hazard

Signal Word

Danger

Hazard Codes

Hazard Classifications

Muta. 2 - Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges



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