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Human DPPIV / CD26 ELISA Kit

Name: Human DPPIV / CD26 ELISA Kit
Brand: SIGMA
Price: 608 USD

for serum, plasma, cell culture supernatant and urine

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Pack Size	SKU	Availability	Price
1 kit		Usually ships in 1 week. (Orders outside of US and Europe, please allow an additional 1-2 weeks for delivery)	$608.00

About This Item

NACRES:

NA.32

UNSPSC Code:

41116158

Gene information:

human ... DPP4(1803)

Input:

sample type serum
sample type cell culture supernatant(s)
sample type plasma
sample type urine

Species reactivity:

human

Storage temp.:

−20°C

Shipped in:

wet ice

$608.00

Usually ships in 1 week. (Orders outside of US and Europe, please allow an additional 1-2 weeks for delivery)

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species reactivity

human

packaging

kit of 96 wells (12 strips x 8 wells)

technique(s)

ELISA: suitable, capture ELISA: suitable

input

sample type serum
sample type cell culture supernatant(s)
sample type plasma
sample type urine

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 25 pg/mL
standard curve range: 32.77-8000 pg/mL

detection method

colorimetric

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... DPP4(1803)

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Enzyme-Linked Immunosorbent Assay (ELISA) Kits

Immunoassay Platform Solutions

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This Item	RAB0087	RAB0062	RAB0407
Sigma-Aldrich RAB0147 Human DPPIV / CD26 ELISA Kit	Sigma-Aldrich RAB0087 Human CD40L ELISA Kit	Sigma-Aldrich RAB0062 Human CCL21 / 6ckine ELISA Kit	Sigma-Aldrich RAB0407 Human Angiostatin ELISA Kit
species reactivity human	species reactivity human	species reactivity human	species reactivity human
Gene Information human ... DPP4(1803)	Gene Information human ... CD40LG(959)	Gene Information human ... CCL21(6366)	Gene Information human ... PLG(5340)
input sample type serum sample type cell culture supernatant(s) sample type plasma sample type urine	input sample type plasma sample type cell culture supernatant(s) sample type serum sample type urine	input sample type plasma sample type serum sample type cell culture supernatant(s) sample type urine	input sample type cell culture supernatant(s) sample type plasma sample type serum sample type urine
assay range inter-assay cv: <12% intra-assay cv: <10% sensitivity: 25 pg/mL standard curve range: 32.77-8000 pg/mL	assay range inter-assay cv: <12% intra-assay cv: <10% sensitivity: 6 pg/mL standard curve range: 8.23-6000 pg/mL	assay range inter-assay cv: <12% intra-assay cv: <10% sensitivity: 30 pg/mL standard curve range: 32.76-8000 pg/mL	assay range inter-assay cv: <12% intra-assay cv: <10% sensitivity: 20000 pg/mL standard curve range: 31.25-2000 ng/mL
detection method colorimetric	detection method colorimetric	detection method colorimetric	detection method colorimetric
technique(s) ELISA: suitable, capture ELISA: suitable	technique(s) ELISA: suitable, capture ELISA: suitable	technique(s) ELISA: suitable, capture ELISA: suitable	technique(s) ELISA: suitable, capture ELISA: suitable

General description

The Human CD26 (also known as DPPIV) ELISA (Enzyme- Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human CD26 in serum, plasma, cell culture supernatants and urine.

Immunogen

Recombinant Human CD26

Application

For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Biochem/physiol Actions

Dipeptidyl peptidase 4 (DPPIV), also known as CD26 (cluster of differentiation 26), is localized on T- cell surface and interacts with adenosine deaminase (ADA), collagen and CD459. It plays a vital role in T cell co-stimulation, cell-to-cell adhesion, and in human immunodeficiency virus (HIV) infection.[1][2] Deletion of the DPPIV gene alters carbohydrate metabolism which in turn leads to mental retardation and hypotonia.[3] Abnormal expression of DPPIV is observed during liver regeneration, human cirrhosis and liver tumorigenesis.[2] DPPIV level is reduced in serum of chronic obstructive pulmonary disease (COPD) patients, hence, this protein has potential as a serologic marker for screening COPD.[4] DPP4 functions as a serine protease enzyme that catalyzes the cleavage of dipeptides from peptides containing proline or alanine residues. IL-13 induced DPPIV expression is upregulated in bronchial epithelial cells (BECs) and this expression might contribute to the development of asthmatic airway inflammation, cell proliferation and fibronectin (FN) production. This protein is a promising biomarker and therapeutic target for asthma.[5]

Other Notes

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

Kit Components Also Available Separately

Product No.

Description

SDS

RABELADAELISA 1X Assay/Sample Diluent Buffer A (Item D1)SDS

RABELADBELISA 5X Assay/Sample Diluent Buffer B (Item E1)SDS

RABSTOP3ELISA Stop Solution (Item I)SDS

RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)SDS

RABWASH420X Wash Buffer (Item B)SDS

pictograms

GHS05

signalword

Warning

hcodes

H290

pcodes

P234 - P390

Hazard Classifications

Met. Corr. 1

Storage Class

10 - Combustible liquids

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Expression and Clinical Significance of Serum Dipeptidyl Peptidase IV Chronic Obstructive Pulmonary Disease.

Xiao-Yue Chang et al.

The American journal of the medical sciences, 351(3), 244-252 (2016-03-20)

The purpose of this study is to explore the correlation between serum dipeptidyl peptidase IV (DPPIV) and chronic obstructive pulmonary disease (COPD) at its various disease states, analyze its applications in the prediction and diagnosis of COPD and test the

Dipeptidyl peptidase-4 is highly expressed in bronchial epithelial cells of untreated asthma and it increases cell proliferation along with fibronectin production in airway constitutive cells.

Taichi Shiobara et al.

Respiratory research, 17, 28-28 (2016-03-16)

Type 2 helper T-cell cytokines including IL-13 play a central role in the pathogenesis of bronchial asthma (BA). During the course of our research, our attention was drawn to dipeptidyl peptidase-4 (DPP4) as one of the molecules that were induced

A novel deletion in 2q24.1q24.2 in a girl with mental retardation and generalized hypotonia: a case report.

Orazio Palumbo et al.

Molecular cytogenetics, 5(1), 1-1 (2012-01-05)

Chromosomal imbalances, recognized as the major cause of mental retardation, are often due to submicroscopic deletions or duplications not evidenced by conventional cytogenetic methods. To date, interstitial deletion of long arm of chromosome 2 have been reported for more than

Molecular analyses of human and rat dipeptidyl peptidase IV.

C A Abbott et al.

Advances in experimental medicine and biology, 421, 161-169 (1997-01-01)

Genomic organization, exact localization, and tissue expression of the human CD26 (dipeptidyl peptidase IV) gene.

C A Abbott et al.

Immunogenetics, 40(5), 331-338 (1994-01-01)

CD26 is a lymphocyte cell surface antigen which is increased during T-cell activation and is also expressed in other tissues. It is an atypical serine protease belonging to the prolyl oligopeptidase family. CD26 has been implicated in a variety of

Global Trade Item Number

SKU	GTIN
RAB0147-1KT	04061834960249

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