Skip to Content
MilliporeSigma

Skip To

S3007

Sodium salicylate

ReagentPlus®, ≥99.5% (titration)

Synonym(s):

2-Hydroxybenzoic acid sodium salt, Salicylic acid sodium salt, Sodium 2-hydroxybenzoate

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Size/SKUAvailabilityPrice
500 g

Available to ship TODAY

$119.00
1 kg

Available to ship TODAY

$164.00
5 kg

Available to ship TODAYfromMILWAUKEE

$647.00

About This Item

Linear Formula:
HOC6H4COONa
CAS Number:
Molecular Weight:
160.10
UNSPSC Code:
12352302
NACRES:
NA.25
PubChem Substance ID:
EC Number:
200-198-0
Beilstein/REAXYS Number:
3732792
MDL number:
Assay:
≥99.5% (titration)
Form:
crystalline
Solubility:
water: 575.7 g/L at 25 °C (77 °F)

$119.00


Available to ship TODAYDetails


​
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist


Quality Segment

product line

ReagentPlus®

assay

≥99.5% (titration)

form

crystalline

color

white

useful pH range

6.85 (26.3 °C)

mp

>300 °C (lit.)

solubility

water: 575.7 g/L at 25 °C (77 °F)

SMILES string

[Na+].Oc1ccccc1C([O-])=O

InChI

1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1

InChI key

ABBQHOQBGMUPJH-UHFFFAOYSA-M

General description

Sodium salicylate is the active ingredient in aspirin, commonly used as antipyretic, anti-inflammatory and analgesic drug. Sodium salicylate when taken in large quantities causes temporary hearing loss and tinnitus. Prolonged treatment with sodium salicylate reduces output from cochlea permanently, reduces compound action potential amplitude in vivo and neural degeneration in vitro. Sodium salicylate treatment in lateral amygdala alters tonography and excitability, causing hyperactivity in auditory cortex. Sodium salicylate impairs the expression of cellular-Finkel−Biskis−Jinkins murine osteogenic sarcoma virus (c-fos) and δ-FosB proteins in hippocampus region and affects spatial memory and learning. Sodium salicylate affects neurogenesis in dentate gyrus region of the brain.

Application

Sodium salicylate has been used:
  • to induce tinnitus, hyperacusis-like behavior in rats and infused directly into amygdala to measure local field potential.
  • to induce and confirm tinnitus by prepulse inhibition behavior (PPI) and its inhibition on learning and memory by Morris water maze test and subsequent gene expression studies in rats.
  • to enhance gamma amino butyric acid (GABA)ergic inhibition and enhance auditory response in the dorsal cortex of the inferior colliculus (ICd) measured by microiontophoretic technique.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
567630PHR3238S0800000
description

ReagentPlus®, ≥99.5% (titration)

description

A cell-permeable, non-steroidal anti-inflammatory agent that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein.

description

pharmaceutical secondary standard, certified reference material

description

European Pharmacopoeia (EP) Reference Standard

form

crystalline

form

solid

form

-

form

-

assay

≥99.5% (titration)

assay

≥98% (titration)

assay

-

assay

-

solubility

water: 575.7 g/L at 25 °C (77 °F)

solubility

water: 50 mg/mL, ethanol: soluble

solubility

-

solubility

-

Quality Level

200

Quality Level

100

Quality Level

300

Quality Level

-

mp

>300 °C (lit.)

mp

-

mp

>300 °C (lit.)

mp

>300 °C (lit.)

useful pH range

6.85 (26.3 °C)

useful pH range

-

useful pH range

-

useful pH range

-


Still not finding the right product?

Explore all of our products under Sodium salicylate


Pictograms

Health hazardExclamation mark

Signal Word

Warning

Hazard Codes

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2

Storage Class

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

208.9 °F - Pensky-Martens closed cup

Flash Point (°C)

98.3 °C - Pensky-Martens closed cup

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Gloves



Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library



Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

Reviews

No rating value

Active Filters