This product has not been tested for bioactivity.
S4316
Amyloid Precursor Protein β, Secreted human
recombinant, expressed in E. coli (N-terminal histidine tagged), solution
Synonym(s):
Amyloid Precursor Protein β, Secreted, sAPPβ
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| Size/SKU | Availability | Price |
|---|---|---|
25 μg | Check Cart for Availability | $878.00 |
About This Item
General description
Amyloid-β (Aβ) peptides are a major component of the senile plaques characteristic of the Alzheimer brain. It is a type- I transmembrane protein. The gene encoding amyloid-β is localized on human chromosome 21.
Application
Human amyloid precursor protein β has been used as peptide standard.
Biochem/physiol Actions
The secreted amyloid precursor β (sAPPβ) is a proteolytic cleavage product of β amyloid precursor protein (APP). APP is cleaved by β-secretase into two fragments, sAPPβ and β-amyloid peptide (Aβ). The Aβ is a component of amyloid plaques, one of the major hallmarks of Alzheimer`s disease (AD), while the sAPPβ is thought to modulate neuronal function and cell survival. Mutation in APP found in Swedish familial AD pedigree increases the susceptibility of APP to β-secretase cleavage and the formation of Aβ and sAPPβ. In contrast, activation of protein kinase C (PKC) decreases the levels of sAPPβ. The trans-Golgi network (TGN) is the major site for β-secretase activity.
Physical form
0.2 μm filtered solution in 20 mM Tris (pH 7.4), 0.5 M NaCl, 1 mM EDTA, 5 mM βME, 2 μg/ml aprotinin
Preparation Note
sAPPβ was expressed in E. coli as a soluble protein and purified under non-denaturing conditions
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This Item | |||
|---|---|---|---|
| description recombinant, expressed in E. coli (N-terminal histidine tagged), solution | description ≥90% (HPLC) | description ≥90% (HPLC), lyophilized powder | description ≥90% (HPLC), powder |
| recombinant expressed in E. coli (N-terminal histidine tagged) | recombinant - | recombinant - | recombinant - |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form solution | form powder | form lyophilized powder | form powder |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
| Gene Information human ... APP(351) | Gene Information human ... APP(351) | Gene Information human ... APP(351) | Gene Information human ... APP(351) |
| storage temp. −70°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
Storage Class
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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