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S7820

α-Synuclein human

recombinant, expressed in E. coli, N-terminal histidine tagged, ≥90% (SDS-PAGE), lyophilized powder

Synonym(s):

α-Synuclein protein, Synuclein protein

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Size/SKUAvailabilityPrice
500 μg

Available to ship TODAYfromMILWAUKEE

$804.00

About This Item

UNSPSC Code:
12352200
NACRES:
NA.32
MDL number:
MFCD06411761

$804.00

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recombinant

expressed in E. coli

Quality Segment

assay

≥90% (SDS-PAGE)

form

lyophilized powder

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... SNCA(6622)

General description

α-Synuclein is an intrinsically disordered protein predominantly expressed in the dopaminergic neurons. It is localized to the presynaptic nerve terminals and is highly conserved in vertebrates.

Application

α-Synuclein human has been used to study the α-syn monomers and its aggregates on paraformaldehyde (PFA)-fixed membrane. It has also been used to study its effect on neurotransmitter levels (monoamines and amino acid concentration) tyrosine hydroxylase (TH) and transglutaminase-2 (TG2) mRNA expression in the mouse striata (ST).
Human α-synuclein has been used to study the immunodetection of α-syn monomers and its aggregates. It has also been used in microscale thermophoresis to study protein-protein interactions.

Biochem/physiol Actions

140-amino acid protein (apparent molecular weight 19-20 kDa) encoded by a simple gene consisting of six exons on human chromosome 4. Induces polymerization of tubulin into microtubules and functions in the modulation of dopamine transporter function, regulating the synaptic tone of dopamine. Disruption of this function can ultimately lead to neurodegeneration of nerve terminals. Highly abundant in presynaptic terminals, a major component of Lewy bodies, the neuronal cytoplasmic inclusions that are a hallmark of diverse neurodegenerative disorders such as Parkinson′s disease (PD), dementia with Lewy bodies (filamentous inclusions), Lewy body variant of Alzheimer′s disease, and multiple system atrophy. Pathogenic point mutations in the α-synuclein gene are linked to familial Parkinson′s disease.
140-amino acid protein (apparent molecular weight 19-20 kDa) that induces polymerization of tubulin into microtubules and functions in the modulation of dopamine.

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α-Synuclein human recombinant, expressed in E. coli, N-terminal histidine tagged, ≥90% (SDS-PAGE), lyophilized powder

Sigma-Aldrich

S7820

α-Synuclein human

Anti-Synuclein α Antibody serum, Chemicon®

Sigma-Aldrich

AB5038

Anti-Synuclein α Antibody

Anti-α-Synuclein antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution

Sigma-Aldrich

S3062

Anti-α-Synuclein antibody produced in rabbit

Anti-α-Synuclein antibody, Mouse monoclonal clone Syn211, purified from hybridoma cell culture

Sigma-Aldrich

S5566

Anti-α-Synuclein antibody, Mouse monoclonal

description

recombinant, expressed in E. coli, N-terminal histidine tagged, ≥90% (SDS-PAGE), lyophilized powder

description

serum, Chemicon®

description

IgG fraction of antiserum, buffered aqueous solution

description

clone Syn211, purified from hybridoma cell culture

recombinant

expressed in E. coli

recombinant

-

recombinant

-

recombinant

-

assay

≥90% (SDS-PAGE)

assay

-

assay

-

assay

-

Quality Level

200

Quality Level

100

Quality Level

200

Quality Level

200

form

lyophilized powder

form

-

form

buffered aqueous solution

form

buffered aqueous solution

shipped in

dry ice

shipped in

dry ice

shipped in

-

shipped in

dry ice

Gene Information

human ... SNCA(6622)

Gene Information

human ... SNCA(6622)

Gene Information

human ... SNCA(6622)
rat ... Snca(29219)

Gene Information

human ... SNCA(6622)

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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