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Anti-Substance P Receptor antibody produced in rabbit

Name: Anti-Substance P Receptor antibody produced in rabbit
Brand: SIGMA

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-NK1R, Anti-SPR

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD01634202

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ARR, IHC (f), WB CL

Citations:

Pricing and availability is not currently available.

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 46 kDa

species reactivity

human, rat, mouse, guinea pig

packaging

antibody small pack of 25 μL

technique(s)

immunohistochemistry (frozen sections): 1:5,000 using 4% paraformaldehyde (with picric acid/glutaraldehyde)-fixed, frozen, rat brain sections., microarray: suitable, western blot (chemiluminescent): 1:2,000 using a rat brain membrane fraction extract

UniProt accession no.

P25103

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TACR1(6869)
mouse ... Tacr1(21336)
rat ... Tacr1(24807)

Description

General description

Substance P receptor (SPR), also known as neurokinin receptor 1 (NK-1 R), is a member of the G-protein-coupled class of seven transmembrane domain receptors. SPR gene with five exons, spanning 45-60kb on genomic DNA, is mapped to human chromosome 2. SPR is highly expressed in central nervous system.

Immunogen

synthetic peptide corresponding to the C-terminal of NK1R of rat origin (amino acids 393-407). This sequence is highly conserved in mouse, guinea pig, and human NK1R, but diverges in other tachykinin receptor subtypes NK2R and NK3R.

Application

Anti-substance P receptor antibody produced in rabbit has been used in immunohistochemistry.[1]

Biochem/physiol Actions

Substance P (SP) exhibits pro-inflammatory, endocrine, neuromodulatory and trophic activities. Substance P receptor (SPR) upon binding to its ligand SP, facilitates extravasation of granulocytes and in inflammation and tissue derangement. In addition, activation of this receptor also enhances metabolism of phosphoinositol, leading to synthesis of inositol-1,4,5-trisphosphate and diacylglycerol which results in release of Ca²⁺ from the endoplasmic reticulum and activation of protein kinase C. SPR along with its ligand stimulates tumoral angiogenesis and cell proliferation in a variety of cancer types. Inhibition of substance P receptor retards the growth of neuroblastoma (NB) cell lines. Thus, SPR might act as a potential therapeutic target for a large variety of patients with neuroblastoma. SP-SPR complex is also implicated in the regulation of the pain transmission.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	S1542	G8913	S1172
$Anti-Substance P Receptor antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich S8305 Anti-Substance P Receptor antibody produced in rabbit	Sigma-Aldrich S1542 Anti-Substance P antibody produced in rabbit	Sigma-Aldrich G8913 Anti-Glutamate Receptor NMDAR1 (NR1) antibody produced in rabbit	$Anti-Syntaxin 1 antibody produced in rabbit IgG fraction of antiserum, lyophilized powder$ Sigma-Aldrich S1172 Anti-Syntaxin 1 antibody produced in rabbit
description IgG fraction of antiserum, buffered aqueous solution	description whole antiserum	description affinity isolated antibody, buffered aqueous solution	description IgG fraction of antiserum, lyophilized powder
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 100
antibody form IgG fraction of antiserum	antibody form whole antiserum	antibody form affinity isolated antibody	antibody form IgG fraction of antiserum
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
technique(s) immunohistochemistry (frozen sections): 1:5,000 using 4% paraformaldehyde (with picric acid/glutaraldehyde)-fixed, frozen, rat brain sections., western blot (chemiluminescent): 1:2,000 using a rat brain membrane fraction extract, microarray: suitable	technique(s) dot blot: 1:20,000, radioimmunoassay: 1:5,000	technique(s) western blot: 1:2,000 using extract of a rat brain synaptosomal fraction.	technique(s) immunohistochemistry: suitable using rat brain sections, western blot (chemiluminescent): 1:1,000 using rat brain membranes
clone polyclonal	clone polyclonal	clone polyclonal	clone polyclonal

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c