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| Size/SKU | Availability | Price |
|---|---|---|
25 units | Estimated to ship onJanuary 22, 2027fromMILWAUKEE | $247.00 |
50 units | Check Cart for Availability | $418.00 |
About This Item
CAS Number:
UNSPSC Code:
12352204
NACRES:
NA.32
EC Number:
MDL number:
Specific activity:
100-300 units/mg protein (Lowry)
form
buffered aqueous glycerol solution
Quality Segment
specific activity
100-300 units/mg protein (Lowry)
storage temp.
2-8°C
Application
Biochem/physiol Actions
Bacterial sphingomyelinase is active at neutral pH. When used in cell culture in vitro, it hydrolyzes the sphingomyelin on the outer leaflet of the plasma membrane and produces ceramide that is lipid-soluble. Sphingomyelinase is the key enzyme in the sphingomyelinase/ceramide pathway, which is implicated in the pathogenesis of several neurodegenerative disorders.
Initiates the formation of sphingomyelin-based second messengers. Activates MAPK (mitogen-activated protein kinase) and SAPKs (stress-activated protein kinases); generates ceramide from sphingomyelin.
Physical form
Solution in 50% glycerol containing 0.25 M phosphate buffer, pH 7.5
Other Notes
One unit will hydrolyze 1.0 μmol of TNPAL-sphingomyelin per min at pH 7.4 at 37 °C.
1 of 1
This Item | |||
|---|---|---|---|
| description buffered aqueous glycerol solution, 100-300 units/mg protein (Lowry) | description - | description - | description lyophilized powder, Protein ~60 % by Lowry, ≥10,000 units/mg protein |
| specific activity 100-300 units/mg protein (Lowry) | specific activity ≥100 units/mg protein | specific activity - | specific activity ≥10,000 units/mg protein |
| form buffered aqueous glycerol solution | form liquid | form lyophilized solid | form lyophilized powder |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C |
| Quality Level 200 | Quality Level 100 | Quality Level 100 | Quality Level 300 |
Storage Class
10 - Combustible liquids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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