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Anti-Collagen Type II (COL2A1) Antibody

Name: Anti-Collagen Type II (COL2A1) Antibody
Brand: SIGMA

rabbit polyclonal

Synonym(s):

CO2A1, chondrocalcin, collagen, collagen α-1 (II), type II

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.43

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA, IF, IHC, WB

Citations:

Pricing and availability is not currently available.

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Properties

Product Name

Anti-Collagen II antibody produced in rabbit, affinity isolated antibody

biological source

rabbit

Quality Segment

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 141 kDa

species reactivity

human, mouse, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:20000, immunofluorescence: 1:100-1:500, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000

NCBI accession no.

P02458

UniProt accession no.

P02458

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... COL2A1(1280)

Description

General description

Anti-Collagen II Antibody detects endogenous levels of total Collagen II protein.

Collagen type II α 1 chain (COL2A1) gene is mapped to human chromosome 12q13.11–q13.12. COL2A1 belongs to collagen superfamily. The encoded protein is characterized with three identical α chains forming homotrimers. Collagen II is the major component of cartilage.

Immunogen

The antiserum was produced against synthesized peptide derived from human Collagen II.

Immunogen Range: 101-150

Application

Anti-Collagen II, N-Terminal antibody produced in rabbit has been used for:

Western blotting
Immunofluorescence
Immunohistological analyses

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (2 papers)

Biochem/physiol Actions

Mutation of collagen type II α 1 chain (COL2A1), leads to a variety of clinical manifestations such as skeletal dysplasia, short stature, and sensorial defects, collectively known as type II collagenopathies. Function of COL2A1 in articular cartilage is to form highly organized fibers, which are essential for the mechanical properties of the tissue.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	AB761	MAB8887	ZRB1201
Sigma-Aldrich SAB4500366 Anti-Collagen II antibody produced in rabbit	Sigma-Aldrich AB761 Anti-Collagen Type II Antibody	Sigma-Aldrich MAB8887 Anti-Collagen Type II Antibody, clone 6B3	Sigma-Aldrich ZRB1201 Anti-Collagen Type II Antibody, clone 1K11 ZooMAb^® Rabbit Monoclonal
description affinity isolated antibody	description Chemicon^®, from rabbit	description clone 6B3, Chemicon^®, from mouse	description recombinant, expressed in HEK 293 cells
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 200
conjugate unconjugated	conjugate -	conjugate -	conjugate unconjugated
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form purified antibody
biological source rabbit	biological source rabbit	biological source mouse	biological source rabbit
species reactivity human, mouse, rat	species reactivity human	species reactivity human, chicken, mouse, salamander	species reactivity human, chicken
technique(s) immunofluorescence: 1:100-1:500, ELISA: 1:20000, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000	technique(s) ELISA: suitable, immunohistochemistry: suitable, immunocytochemistry: suitable, western blot: suitable	technique(s) western blot: suitable, immunofluorescence: suitable, immunohistochemistry: suitable	technique(s) western blot: suitable, flow cytometry: suitable, immunocytochemistry: suitable, immunohistochemistry: suitable, ELISA: suitable

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Storage Class

12 - Non Combustible Liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)