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SAE0117

Amelogenin, human

X isoform, recombinant, expressed in E. coli

Synonym(s):

AIH1, AMELX, AMG, AMGX, Amel

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Size/SKUAvailabilityPrice
0.5 mg

Available to ship TODAYfromMILWAUKEE

$564.00

About This Item

NACRES:
NA.26
UNSPSC Code:
12352202
Form:
solid
Assay:
≥90% (HPLC)
Biological source:
human
Recombinant:
expressed in E. coli

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biological source

human

Quality Segment

recombinant

expressed in E. coli

assay

≥90% (HPLC)

form

solid

impurities

≤1 EU/μg

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... AMELX(265)

General description

Research area: Neuroscience

Amelogenin, X isoform belongs to the family of closely related amelogenin proteins that participate in the amelogenesis process of teeth mineralization. Amelogenins account for more than 90% of the total protein in developing tooth enamel.

Biochem/physiol Actions

Mutations in AMELX are responsible for the development of the rare disease Amelogenesis imperfecta 1E (AI1E), which is characterized by abnormal tooth enamel development. Amelogenins act both as attachment factors and as a growth factor for mesenchymal stem cells. Amelogenin is of increasing importance as a potential therapeutic agent for variety of application including treatment hard-to-heal wounds, promoting remineralization of caries lesions, and repairing human tooth enamel.

Preparation Note

The product can be reconstituted in water or 2% acetic acid in a concentration of 0.1-5 mg/ml. Tap vial to make sure protein is reconstituted. Aliquot reconstituted Amelogenin and store at -20 °C. Avoid repeated freeze/thaw cycles. Amelogenin may form thin clear film on some surfaces, leading to reduced concentration in solution. Exact Amelogenin concentration can be determined by absorption at 280nm. Amelogenin solution of 0.1% has A280=1.35

Other Notes

The product is supplied as lyophilized powder, prepared from a 0.2 μM filtered solution of Amelogenin in 2% acetic acid without any additives. The lyophilized product is essentially salt free. The biological activity of recombinant, human AMELX is measured by its ability to promote attachment of Saos-2 cells to a coated surface. The ED50 is defined as the amount of AMELX per cm2 that elicits 50% of the maximal attachment activity.

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Sigma-Aldrich

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Anti-Amelogenin, X isoform/AMELX Antibody

Monoclonal Anti-ENAM antibody produced in mouse clone 2C12, purified immunoglobulin, buffered aqueous solution

Sigma-Aldrich

SAB1401509

Monoclonal Anti-ENAM antibody produced in mouse

description

X isoform, recombinant, expressed in E. coli

description

The Bone morphogenetic protein 4 (or BMP-4 protein) is a TGFβ superfamily ligand that is widely expressed from early embryogenesis through adulthood.

description

serum, from rabbit

description

clone 2C12, purified immunoglobulin, buffered aqueous solution

biological source

human

biological source

-

biological source

rabbit

biological source

mouse

assay

≥90% (HPLC)

assay

>97% (SDS-PAGE and HPLC)

assay

-

assay

-

recombinant

expressed in E. coli

recombinant

-

recombinant

-

recombinant

-

form

solid

form

-

form

-

form

buffered aqueous solution

storage temp.

−20°C

storage temp.

-10 to -25°C

storage temp.

-

storage temp.

−20°C

shipped in

wet ice

shipped in

dry ice

shipped in

wet ice

shipped in

dry ice

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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