If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
SMB00610
Lipopolysaccharide from Porphyromonas gingivalis
purified by phenol extraction
Synonym(s):
LPS
Select a Size
| Size/SKU | Availability | Price |
|---|---|---|
1 mg | Available to ship TODAYfromMILWAUKEE | $396.00 |
About This Item
biological source
Porphyromonas gingivalis
Quality Segment
form
powder
purified by
phenol extraction
impurities
≤3% Protein (Lowry)
color
white to faint yellow
solubility
triethylene glycol dimethyl ether: 0.90-1.10 mg/mL to hazy, colorless to light yellow
shipped in
ambient
storage temp.
2-8°C
General description
Application
- as a treatment to stimulate acute lung injury in human bronchial epithelial (HBE) cells
- as an agonist for toll-like receptor 4 (TLR4) and to stimulate intestinal normal fibroblasts (NFs) to study osteopontin (OPN) expression in myofibroblasts
- to study its effects on pro-inflammatory and pro-coagulant genes expression in endothelial cells
Biochem/physiol Actions
Additionally, it was demonstrated that the mechanisms by which LPS from E. coli and P. gingivalis modulate cluster of differentiation 14 (CD14), toll-like receptor 2 (TLR2), and toll-like receptor 4 (TLR4) surface expression, primary and secondary cytokine responses are different.
Porphyromonas gingivalis is a Gram-negative bacterium that is known to be involved in adult periodontitis. Periodontitis is a chronic inflammatory disease characterized by the recession of the supportive tissue surrounding teeth. Studies have shown that the LPS from P. gingivalis plays an important role in this disease.
A recent study demonstrated that LPS from P. gingivalis stimulates insulin secretion by the pancreatic β cell line, MIN6. In the presence of 5 mM glucose and 50-500 ng/mL LPS from P. gingivalis, a significant induction of insulin secretion was observed.
Preparation Note
Other Notes
1 of 1
This Item | |||
|---|---|---|---|
| description purified by phenol extraction | description purified by phenol extraction | description purified by phenol extraction | description purified by phenol extraction |
| biological source Porphyromonas gingivalis | biological source bacterial (Proteus vulgaris) | biological source Escherichia coli (O55:B5) | biological source Escherichia coli (O111:B4) |
| solubility triethylene glycol dimethyl ether: 0.90-1.10 mg/mL to hazy, colorless to light yellow | solubility water: 4.90-5.10 mg/mL, faintly hazy to hazy, colorless to faintly yellow | solubility water: soluble | solubility water: soluble |
| Quality Level 200 | Quality Level 200 | Quality Level 300 | Quality Level 300 |
| form powder | form lyophilized powder | form lyophilized powder | form lyophilized powder |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| impurities ≤3% Protein (Lowry) | impurities ≤3% Protein (Lowry) | impurities <3% Protein (Lowry) | impurities ≤3.00% protein (Lowry-TCA) |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
-
How can I determine the shelf life / expiration / retest date of this product?
1 answer-
Helpful?
-
-
How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
Helpful?
-