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SML0229

CIQ

≥98% (HPLC)

Synonym(s):

(3-Chlorophenyl)[3,4-dihydro-6,7-dimethoxy-1-[(4-methoxyphenoxy)methyl]-2(1H)-isoquinolinyl]-methanone

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Size/SKUAvailabilityPrice
25 mg

Estimated to ship onAugust 13, 2026fromMILWAUKEE

$594.00

About This Item

Empirical Formula (Hill Notation):
C26H26ClNO5
CAS Number:
Molecular Weight:
467.94
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$594.00


Estimated to ship onAugust 13, 2026Details


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: ≥10 mg/mL at warmed to 60 °C

storage temp.

2-8°C

SMILES string

Clc1cc(ccc1)C(=O)N2CCc3c(cc(c(c3)OC)OC)C2COc4ccc(cc4)OC

InChI

1S/C26H26ClNO5/c1-30-20-7-9-21(10-8-20)33-16-23-22-15-25(32-3)24(31-2)14-17(22)11-12-28(23)26(29)18-5-4-6-19(27)13-18/h4-10,13-15,23H,11-12,16H2,1-3H3

InChI key

VYMILMYEENZHAR-UHFFFAOYSA-N

Biochem/physiol Actions

CIQ is a selective NR2C/NR2D-containing NMDA potentiator
CIQ is positive allosteric modulator of NR2C/NR2D subunit containing NMDA receptors. CIQ increases channel opening frequency of recombinant NR2Cor NR2D containing receptors by two-fold (EC50 = 2.7 and 2.8 μM, respectively), with no effect on NR2A or NR2B subtypes. The compound does not alter the EC50 values for glutamate or glycine on channel opening.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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assay

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assay

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assay

≥98% (HPLC)

form

powder

form

solid

form

buffered aqueous glycerol solution

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

-

storage temp.

−20°C

storage temp.

2-8°C

solubility

DMSO: ≥10 mg/mL at warmed to 60 °C

solubility

DMSO: 15 mg/mL

solubility

-

solubility

H2O: <2 mg/mL, DMSO: >20 mg/mL

color

white to beige

color

off-white

color

-

color

yellow


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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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