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SML0330

S3I-201

≥97% (HPLC)

Synonym(s):

2-Hydroxy-4-[[[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid, NSC 74859

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$121.00
$102.85
25 mg

Available to ship TODAYfromMILWAUKEE

$510.00
$433.50

About This Item

Empirical Formula (Hill Notation):
C16H15NO7S
CAS Number:
Molecular Weight:
365.36
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥97% (HPLC)
Form:
powder

$102.85

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Quality Segment

assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

DMSO: >10 mg/mL

storage temp.

−20°C

SMILES string

Cc1ccc(cc1)S(=O)(=O)OCC(=O)Nc2ccc(C(O)=O)c(O)c2

InChI

1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22,23)24-9-15(19)17-11-4-7-13(16(20)21)14(18)8-11/h2-8,18H,9H2,1H3,(H,17,19)(H,20,21)

InChI key

HWNUSGNZBAISFM-UHFFFAOYSA-N

Application

S3I-201 has been used as a signal transducer and activator of transcription 3 (STAT3) inhibitor:
  • to confirm the role of STAT3 phosphorylation in interleukin (IL)-33 production in lung epithelial cells and IL-22 mRNA expression in sorted group 3 innate lymphoid cells (ILC3s)
  • to study the cellular response of STAT3 triggered by β-hexaclorocyclohexane (β-HCH) in various cell lines
  • to examine the influence of STAT3 in response to angiotensin II (ang II) on induction of fibrotic proteins in kidney epithelial cells

Biochem/physiol Actions

S3I-201 is a cell-permeable Stat3 inhibitor that binds to the Stat3-SH2 domain, prevents Stat3 phosphorylation/activation, dimerization, and DNA-binding.
S3I-201 is a cell-permeable Stat3 inhibitor.
Inhibition of signal transducer and activator of transcription 3 (STAT3) activity by S3I-201 may be a potential therapeutic strategy for hypertensive kidney disease.

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This Item
SML1726SML1492SML1907
description

≥97% (HPLC)

description

≥95% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

≥97% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

room temp

solubility

DMSO: >10 mg/mL

solubility

DMSO: 25 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

color

white to beige

color

off-white to purple

color

white to beige

color

white to beige


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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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