SML0330

S3I-201

Name: S3I-201
Brand: SIGMA
Price: 102.85 USD
Availability: InStock

≥97% (HPLC)

Synonym(s):

2-Hydroxy-4-[[[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid, NSC 74859

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₅NO₇S

CAS Number:

501919-59-1

Molecular Weight:

365.36

NACRES:

NA.77

PubChem Substance ID:

329825335

UNSPSC Code:

12352200

MDL number:

MFCD09907564

Key Documents

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Product Name

S3I-201, ≥97% (HPLC)

InChI

1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22,23)24-9-15(19)17-11-4-7-13(16(20)21)14(18)8-11/h2-8,18H,9H2,1H3,(H,17,19)(H,20,21)

SMILES string

Cc1ccc(cc1)S(=O)(=O)OCC(=O)Nc2ccc(C(O)=O)c(O)c2

InChI key

HWNUSGNZBAISFM-UHFFFAOYSA-N

assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

DMSO: >10 mg/mL

storage temp.

−20°C

Quality Level

100

Related Categories

Bioactive Small Molecule Inhibitors

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Show Differences

1 of 4

This Item	SML1726	SML1492	SML1907
Sigma-Aldrich SML0330 S3I-201	Sigma-Aldrich SML1726 MSAB	Sigma-Aldrich SML1492 UMI-77	Sigma-Aldrich SML1907 ESI-05
form powder	form powder	form powder	form powder
assay ≥97% (HPLC)	assay ≥95% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. room temp
solubility DMSO: >10 mg/mL	solubility DMSO: 25 mg/mL, clear	solubility DMSO: 20 mg/mL, clear	solubility DMSO: 20 mg/mL, clear
color white to beige	color off-white to purple	color white to beige	color white to beige

Application

S3I-201 has been used as a signal transducer and activator of transcription 3 (STAT3) inhibitor:

to confirm the role of STAT3 phosphorylation in interleukin (IL)-33 production in lung epithelial cells [1] and IL-22 mRNA expression in sorted group 3 innate lymphoid cells (ILC3s)[2]
to study the cellular response of STAT3 triggered by β-hexaclorocyclohexane (β-HCH) in various cell lines[3]
to examine the influence of STAT3 in response to angiotensin II (ang II) on induction of fibrotic proteins in kidney epithelial cells[4]

Biochem/physiol Actions

Inhibition of signal transducer and activator of transcription 3 (STAT3) activity by S3I-201 may be a potential therapeutic strategy for hypertensive kidney disease.[4]

S3I-201 is a cell-permeable Stat3 inhibitor that binds to the Stat3-SH2 domain, prevents Stat3 phosphorylation/activation, dimerization, and DNA-binding.

S3I-201 is a cell-permeable Stat3 inhibitor.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids.

Kwang Bo Jung et al.

Nature communications, 9(1), 3039-3039 (2018-08-04)

Human pluripotent stem cell (hPSC)-derived intestinal organoids (hIOs) form 3D structures organized into crypt and villus domains, making them an excellent in vitro model system for studying human intestinal development and disease. However, hPSC-derived hIOs still require in vivo maturation

Blockade of STAT3 Causes Severe In Vitro and In Vivo Maturation Defects in Intestinal Organoids Derived from Human Embryonic Stem Cells.

Kwang Bo Jung et al.

Journal of clinical medicine, 8(7) (2019-07-07)

Human intestinal organoids (hIOs), which resemble the human intestine structurally and physiologically, have emerged as a new modality for the study of the molecular and cellular biology of the intestine in vitro. We recently developed an in vitro maturation technique

Chlorogenic acid suppresses lipopolysaccharide‑induced nitric oxide and interleukin‑1β expression by inhibiting JAK2/STAT3 activation in RAW264.7 cells.

Sang-Hun Kim et al.

Molecular medicine reports, 16(6), 9224-9232 (2017-10-11)

Chlorogenic acid (CA) is a phenolic compound purified from coffee, fruits and their associated beverages, which possess various biological properties, such as antioxidant and anticarcinogenic activities. The present study evaluated the effects of CA on lipopolysaccharide (LPS)‑induced inflammation in RAW264.7

Inhibition of the EGFR/STAT3/CEBPD Axis Reverses Cisplatin Cross-resistance with Paclitaxel in the Urothelial Carcinoma of the Urinary Bladder.

Wei-Jan Wang et al.

Clinical cancer research : an official journal of the American Association for Cancer Research, 23(2), 503-513 (2016-07-21)

Cisplatin (CDDP) is frequently used in combination chemotherapy with paclitaxel for treating urothelial carcinoma of the urinary bladder (UCUB). CDDP cross-resistance has been suggested to develop with paclitaxel, thus hindering successful UCUB treatment. Therefore, elucidating the mechanisms underlying CDDP-induced anticancer

Runx1-Stat3 signaling regulates the epithelial stem cells in continuously growing incisors.

Safiye E Sarper et al.

Scientific reports, 8(1), 10906-10906 (2018-07-22)

Rodent incisors grow permanently and the homeostasis of enamel production is maintained by a continuous supply of epithelial progenitors from putative stem cells in the cervical loop. We herein report that Runx1 regulates the Lgr5-expressing epithelial stem cells and their

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S3I-201