The compound is blood-brain barrier permeable, as indicated by a review published in J Physiol. 2009 Jan 1; 587(Pt 1): 49–60, titled "Pharmacological targeting of the serotonergic system for the treatment of obesity" (PMID: 19029184)
SML0588
CP-94,253 dihydrochloride
≥98% (HPLC)
Synonym(s):
1,4-Dihydro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-5H-pyrrol[3,2-b]pyridin-5-one dihydrochloride, 3- (1,2,5,6-Tetrahydro-4-pyridyl)-5-propoxypyrrolo[3, 2-b] pyridine hydrochloride, 5-Propoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-pyrrolo[3,2-b]pyridine hydrochloride, CP-94253 hydrochloride
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| Size/SKU | Availability | Price |
|---|---|---|
25 mg | Available to ship TODAYfromMILWAUKEE | $452.00 |
About This Item
Empirical Formula (Hill Notation):
C15H19N3O · 2HCl
CAS Number:
Molecular Weight:
330.25
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
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Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 15 mg/mL, clear
storage temp.
room temp
SMILES string
Cl.Cl.CCCOc1ccc2[nH]cc(C3=CCNCC3)c2n1
InChI
1S/C15H19N3O.2ClH/c1-2-9-19-14-4-3-13-15(18-14)12(10-17-13)11-5-7-16-8-6-11;;/h3-5,10,16-17H,2,6-9H2,1H3;2*1H
InChI key
HGFPLQPNCZQRLO-UHFFFAOYSA-N
Biochem/physiol Actions
CP-94,253 is a potent and selective serotonin 5-HT1B receptor agonist with approximately 25x and 40x selectivity over the closely related 5-HT1D and 5-HT1A receptors. Ki values are 89, 2, 860, 49 and 1,600 nM for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D and 5-HT2 receptors respectively. CP-94,253 was found to be anxiolytic in animal models; dose-dependently enhanced reinforcing effects of cocaine (self-administration);and reduced food intake.
CP-94,253 is a potent and selective serotonin 5-HT1B receptor agonist.
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This Item | ||
|---|---|---|
| description ≥98% (HPLC) | description ≥98% (HPLC) | description ≥98% (HPLC) |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form powder | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. room temp | storage temp. 2-8°C | storage temp. 2-8°C |
| storage condition desiccated | storage condition - | storage condition - |
| solubility H2O: 15 mg/mL, clear | solubility DMSO: 2 mg/mL, clear | solubility DMSO: >10 mg/mL |
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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