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SML0764

Senktide trifluoroacetate salt

≥95% (HPLC)

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Synonym(s):

DFFGLM (Modifications: Asp-1 = Succinyl-Asp, Phe-3 = Me-Phe, Met-6 = C-terminal amide) trifluoroacetate salt, Suc-Asp-Phe-MePhe-Gly-Leu-Met-NH2 trifluoroacetate salt

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Size/SKUAvailabilityPrice
500 μg
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$148.00

About This Item

Empirical Formula (Hill Notation):
C40H55N7O11S · xC2HF3O2
CAS Number:
Molecular Weight:
841.97 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
film
Storage condition:
desiccated

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Quality Segment

assay

≥95% (HPLC)

form

film

storage condition

desiccated

color

colorless

shipped in

wet ice

storage temp.

−20°C

SMILES string

S(CC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](N(C)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)CCC(=O)O)CC(=O)O)Cc2ccccc2)Cc1ccccc1)CC(C)C)C(=O)N)C

InChI

1S/C40H55N7O11S/c1-24(2)19-28(37(55)45-27(36(41)54)17-18-59-4)44-33(49)23-42-39(57)31(21-26-13-9-6-10-14-26)47(3)40(58)30(20-25-11-7-5-8-12-25)46-38(56)29(22-35(52)53)43-32(48)15-16-34(50)51/h5-14,24,27-31H,15-23H2,1-4H3,(H2,41,54)(H,42,57)(H,43,48)(H,44,49)(H,45,55)(H,46,56)(H,50,51)(H,52,53)/t27-,28-,29-,30-,31-/m0/s1

InChI key

HMHYXLVEFVGOPM-QKUYTOGTSA-N

Biochem/physiol Actions

Senktide is a selective Neurokinin NK3 tachykinin receptor agonist.
Senktide is a selective Neurokinin NK3 tachykinin receptor agonist. Neurokinins (tachykinins) are members of a family of at least three neuropeptides, substance P, neurokinin A, and neurokinin B (NKB), with each mediating their biological effects through binding to a preferred G-protein-coupled receptor termed NK1, NK2, or NK3, respectively. All three NK receptors are expressed in regions of the central nervous system that are related to emotion and cognition (i.e., amygdala and hippocampus) and have been linked to various degrees in psychiatric disorders. Neurokinin receptors, including NK3 receptors, are also expressed in the motor and sensory systems of the digestive tract.
Senktide treatment in follicular phase goats enhances the liberation of luteinizing hormone (LH) and advance the time of ovulation. Senktide has the ability to suppress gonadotropin-releasing hormone (GnRH) transcription. Treatment with senktide stimulates c-Fos and improve activator protein-1 (AP-1) activity.

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This Item
SML2626SML1132SML1773
description

≥95% (HPLC)

description

≥95% (HPLC)

description

≥95% (HPLC), powder

description

≥98% (HPLC)

form

film

form

film

form

powder

form

lyophilized powder

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage condition

desiccated

storage condition

desiccated

storage condition

-

storage condition

protect from light

shipped in

wet ice

shipped in

-

shipped in

wet ice

shipped in

wet ice


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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