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SML0771

LG100754

≥98% (HPLC)

Synonym(s):

(2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-2-naphthalenyl)-2,4,6-Octatrienoic acid

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Pack SizeSKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$148.00
$125.80
25 mg

Available to ship TODAYfromMILWAUKEE

$599.00
$509.15

About This Item

Empirical Formula (Hill Notation):
C26H36O3
CAS Number:
180713-37-5
Molecular Weight:
396.56
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$125.80

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Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

O(CCC)c1cc2c(cc1\C(=C/C=C/C(=C/C(=O)O)/C)\C)C(CCC2(C)C)(C)C

InChI

1S/C26H36O3/c1-8-14-29-23-17-22-21(25(4,5)12-13-26(22,6)7)16-20(23)19(3)11-9-10-18(2)15-24(27)28/h9-11,15-17H,8,12-14H2,1-7H3,(H,27,28)/b10-9+,18-15+,19-11-

InChI key

HNODNXQAYXJFMQ-LQUSFLDPSA-N

Biochem/physiol Actions

LG100754 is a RXR:PPAR agonist.
LG100754 is a unique RXR ligand that acts as an antagonist against RXR homodimers, but is a strong agonist for RXR:PPARα and RXR:PPARγ heterodimers. The compound does not have agonist activities for other RXR heterodimers containing LXR or GAR/FXR receptors. LG100754 initiates adipocyte differentiation, inhibits TNFα-induced insulin receptor hypophosphorylation and improves insulin resistance in db/db mice.

Features and Benefits

This compound is featured on the InsR, Nuclear Receptors (Non-Steroids) and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
SML2015SML1950N8164
LG100754 ≥98% (HPLC)

Sigma-Aldrich

SML0771

LG100754

MM11253 ≥98% (HPLC)

Sigma-Aldrich

SML2015

MM11253

UVI3003 ≥98% (HPLC)

Sigma-Aldrich

SML1950

UVI3003

NSC727447 ≥98% (HPLC)

Sigma-Aldrich

N8164

NSC727447

form

powder

form

powder

form

powder

form

solid

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

room temp

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: >10 mg/mL

color

white to beige

color

white to beige

color

white to beige

color

-

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000164575
0000164577
0000164575
0000164577
0000115190

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Articles

Nuclear Receptors: PPARs

Peroxisome proliferator activated receptors (PPARs) are ligand-activated transcription factors related to hormone receptors, influencing gene expression.

Nuclear Receptors (Non-Steroids)

We offer many products related to non-steroid nuclear receptors for your research needs.

Related Content

InsR

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Global Trade Item Number

SKUGTIN
SML0771-25MG04061837107085
SML0771-5MG04061832955049

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