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SML0848

LM22A-4

≥98% (HPLC), Potent TrkB agonist, powder

Synonym(s):

N1,N3,N5-Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide

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Size/SKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
$147.00
$124.95
25 mg
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$466.00
$396.10

About This Item

Empirical Formula (Hill Notation):
C15H21N3O6
CAS Number:
37988-18-4
Molecular Weight:
339.34
UNSPSC Code:
51111800
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$124.95

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Product Name

LM22A-4, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

N(CCO)C(=O)c1cc(cc(c1)C(=O)NCCO)C(=O)NCCO

InChI

1S/C15H21N3O6/c19-4-1-16-13(22)10-7-11(14(23)17-2-5-20)9-12(8-10)15(24)18-3-6-21/h7-9,19-21H,1-6H2,(H,16,22)(H,17,23)(H,18,24)

InChI key

RGWJKANXFYJKHN-UHFFFAOYSA-N

Application

LM22A-4 has been used as a component of dissociation medium for mouse embryonic stem cells (mESC) and human embryonic stem (hESC) aggregates.

Biochem/physiol Actions

LM22A-4 is a partial agonist of TrkB, a brain-derived neurotrophic factor (BDNF) receptor. In binding assays, LM22A-4 displaces BDNF with an IC50 of 47 nM. The compound restores TrkB phosphorylation and respiratory function in a mouse model of Rett syndrome.
LM22A-4 is a partial agonist of TrkB.
LM22A-4 is a non-peptide and shares similarity with brain-derived neurotrophic factor (BDNF), especially in the loop2 region. It improves oligodendroglia density and favors myelin repair. LM22A-4 elevates the expression of protein kinase B (PKB or Akt) and extracellular signal-regulated kinases (ERKs). LM22A-4 elicits neuroprotection in spinal cord injury (SCI) by deregulating the cleaved-caspase-3 and favoring B-cell lymphoma 2(Bcl-2) expression.

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This Item
B8063SML1814SML0906
LM22A-4 ≥98% (HPLC)

Sigma-Aldrich

SML0848

LM22A-4

BML-210 ≥98% (HPLC), powder

Sigma-Aldrich

B8063

BML-210

3,6-DMAD hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML1814

3,6-DMAD hydrochloride

HPOB ≥98% (HPLC)

Sigma-Aldrich

SML0906

HPOB

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

H2O: 2 mg/mL, clear (warmed)

solubility

DMSO: >20 mg/mL

solubility

DMSO: 25 mg/mL, clear

solubility

DMSO: 1 mg/mL, clear (warmed)

color

white to beige

color

white to very faintly yellow

color

yellow to orange

color

white to beige

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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